The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma.
CD8
HPV
PD-L1
oropharyngeal squamous cell carcinoma
tumor-infiltrating lymphocytes
Journal
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
ISSN: 1600-0714
Titre abrégé: J Oral Pathol Med
Pays: Denmark
ID NLM: 8911934
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
01
04
2020
revised:
24
05
2020
accepted:
27
05
2020
pubmed:
10
6
2020
medline:
22
12
2020
entrez:
10
6
2020
Statut:
ppublish
Résumé
We examined PD-L1 expression on tumor cells (TCs) and immune cells (ICs) and density of CD3 In a cohort of 65 patients treated by definitive intensity-modulated radiotherapy (IMRT) with curative intent, immunohistochemical analysis of PD-L1 expression on TCs and ICs, and TIL subtyping was performed on primary biopsy tumor tissues, followed by prognostic evaluation of these immune response-related parameters including classification into four tumor immune microenvironment (TIM) types. To evaluate HPV status, p16 immunohistochemistry was performed. Densities of CD3 The prognostic and predictive role of tumor immune microenvironment was confirmed for patients with OPSCC. Combining HPV status with the evaluation of densities of CD8
Sections du résumé
BACKGROUND
BACKGROUND
We examined PD-L1 expression on tumor cells (TCs) and immune cells (ICs) and density of CD3
METHODS
METHODS
In a cohort of 65 patients treated by definitive intensity-modulated radiotherapy (IMRT) with curative intent, immunohistochemical analysis of PD-L1 expression on TCs and ICs, and TIL subtyping was performed on primary biopsy tumor tissues, followed by prognostic evaluation of these immune response-related parameters including classification into four tumor immune microenvironment (TIM) types. To evaluate HPV status, p16 immunohistochemistry was performed.
RESULTS
RESULTS
Densities of CD3
CONCLUSION
CONCLUSIONS
The prognostic and predictive role of tumor immune microenvironment was confirmed for patients with OPSCC. Combining HPV status with the evaluation of densities of CD8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
886-896Subventions
Organisme : Ministry of Health, Czech Republic
ID : 00209805
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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