Inhibition of ABCC6 Transporter Modifies Cytoskeleton and Reduces Motility of HepG2 Cells via Purinergic Pathway.
Adenosine Triphosphate
/ metabolism
Cell Cycle
/ drug effects
Cell Movement
Cytoskeleton
/ drug effects
Extracellular Space
/ metabolism
Gene Expression Regulation, Neoplastic
/ drug effects
Gene Silencing
/ drug effects
Hep G2 Cells
Humans
Multidrug Resistance-Associated Proteins
/ antagonists & inhibitors
Probenecid
/ pharmacology
Purines
/ metabolism
ABCC6
ATP
HepG2
cell motility
cytoskeleton
probenecid
purinergic pathway
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
05 06 2020
05 06 2020
Historique:
received:
19
03
2020
revised:
29
05
2020
accepted:
01
06
2020
entrez:
11
6
2020
pubmed:
11
6
2020
medline:
6
3
2021
Statut:
epublish
Résumé
ABCC6, belonging to sub-family C of ATP-binding cassette transporter, is an ATP-dependent transporter mainly present in the basolateral plasma membrane of hepatic and kidney cells. Although the substrates transported are still uncertain, ABCC6 has been shown to promote ATP release. The extracellular ATP and its derivatives di- and mono-nucleotides and adenosine by acting on specific receptors activate the so-called purinergic pathway, which in turn controls relevant cellular functions such as cell immunity, inflammation, and cancer. Here, we analyzed the effect of
Identifiants
pubmed: 32517079
pii: cells9061410
doi: 10.3390/cells9061410
pmc: PMC7349786
pii:
doi:
Substances chimiques
ABCC6 protein, human
0
Multidrug Resistance-Associated Proteins
0
Purines
0
Adenosine Triphosphate
8L70Q75FXE
Probenecid
PO572Z7917
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Trends Biochem Sci. 2019 Feb;44(2):125-140
pubmed: 30446375
Protein Pept Lett. 2010 Dec;17(12):1553-8
pubmed: 20858202
Immunol Lett. 2019 Jan;205:16-24
pubmed: 30439478
Biomed Res Int. 2014;2014:460654
pubmed: 25126561
Front Mol Biosci. 2018 Aug 14;5:75
pubmed: 30155470
Int J Mol Sci. 2018 Mar 11;19(3):
pubmed: 29534490
Cancer Cell. 2019 Dec 9;36(6):582-596
pubmed: 31821783
Int J Mol Sci. 2018 Apr 18;19(4):
pubmed: 29669994
J Bioenerg Biomembr. 2016 Jun;48(3):259-67
pubmed: 26942607
Ann Oncol. 2016 Sep;27(9):1788-93
pubmed: 27287205
Purinergic Signal. 2019 Mar;15(1):53-67
pubmed: 30809739
FEBS Lett. 2015 Dec 21;589(24 Pt B):3921-8
pubmed: 26545497
Purinergic Signal. 2012 Sep;8(3):437-502
pubmed: 22555564
BMC Urol. 2018 Mar 27;18(1):22
pubmed: 29587736
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20206-11
pubmed: 24277820
J Cell Physiol. 2019 Jul;234(7):10248-10259
pubmed: 30417547
Physiol Rev. 2008 Apr;88(2):489-513
pubmed: 18391171
Eur J Med Chem. 2018 Sep 5;157:1051-1055
pubmed: 30176535
Cell Mol Biol Lett. 2017 Apr 4;22:7
pubmed: 28536638
Cancer Res. 2011 May 1;71(9):3410-21
pubmed: 21531766
J Biol Chem. 2017 Feb 3;292(5):1559-1572
pubmed: 27994049
Front Pharmacol. 2016 Nov 07;7:416
pubmed: 27872592
Oncol Rev. 2016 Nov 14;10(2):309
pubmed: 27994771
Am J Physiol Cell Physiol. 2008 Sep;295(3):C761-7
pubmed: 18596212
Cell Mol Biol Lett. 2014 Dec;19(4):517-26
pubmed: 25169437
J Bioenerg Biomembr. 2011 Oct;43(5):465-71
pubmed: 21748403
Nat Rev Cancer. 2018 Oct;18(10):601-618
pubmed: 30006588
Cell Death Differ. 2007 Jul;14(7):1315-23
pubmed: 17396131
Cancer Genomics Proteomics. 2006 Mar-Apr;3(2):97-106
pubmed: 31394687
Clin Cancer Res. 2007 Dec 15;13(24):7296-304
pubmed: 18094410
Oncoimmunology. 2017 Apr 5;6(5):e1312044
pubmed: 28638737
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1985-9
pubmed: 24969777
PLoS One. 2018 Jan 31;13(1):e0192180
pubmed: 29385210
Circ Res. 2013 May 24;112(11):e148-51
pubmed: 23625951
Acta Pharmacol Toxicol (Copenh). 1965;23(4):329-36
pubmed: 5899691
Cancer Cell Int. 2010 May 11;10:16
pubmed: 20459793
Int J Mol Sci. 2017 Sep 11;18(9):
pubmed: 28891970
Ann Transl Med. 2019 Dec;7(24):798
pubmed: 32042814
J Biol Chem. 2018 Oct 12;293(41):15855-15866
pubmed: 30154241
Hematol Rep. 2017 Dec 22;9(4):7406
pubmed: 29333226
Pharmacogenomics J. 2010 Jun;10(3):191-9
pubmed: 20038957
BMC Cancer. 2017 Feb 15;17(1):135
pubmed: 28202050
Cancers (Basel). 2017 Oct 14;9(10):
pubmed: 29036915
Biochim Biophys Acta Biomembr. 2019 Feb 1;1861(2):380-386
pubmed: 30423326
Medicine (Baltimore). 2019 Dec;98(50):e18347
pubmed: 31852133
Eur J Med Chem. 2019 Feb 15;164:1-7
pubmed: 30583246