Cerebrospinal fluid findings in patients with hematologic neoplasms and meningeal infiltration.
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers
/ cerebrospinal fluid
Child
Child, Preschool
Female
Flow Cytometry
/ methods
Hematologic Neoplasms
/ cerebrospinal fluid
Humans
Infant
Lactic Acid
/ cerebrospinal fluid
Male
Meningeal Neoplasms
/ cerebrospinal fluid
Middle Aged
Retrospective Studies
Young Adult
Cerebrospinal fluid
Cytomorphology
Flow cytometry
Hematological neoplasm
Meningeal infiltration
Journal
Acta neurologica Belgica
ISSN: 2240-2993
Titre abrégé: Acta Neurol Belg
Pays: Italy
ID NLM: 0247035
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
05
03
2020
accepted:
02
06
2020
pubmed:
11
6
2020
medline:
23
2
2022
entrez:
11
6
2020
Statut:
ppublish
Résumé
Neoplastic cell infiltration into the central nervous system (CNS) is a serious complication of hematological neoplasms. Cytomorphology (CM) and flow cytometry (FC) have been used to detect meningeal infiltration. The association between CSF findings with the results of CM and FC is still poorly understood. We retrospectively evaluated CSF findings in 72 patients with hematological neoplasm and meningeal infiltration detected either by CM or FC. We compared CSF cell count, total protein concentration, and lactate concentration according to the type of hematological neoplasm. We also compared these CSF findings according to the FC and CM results (FC + CM + , FC + CM-, and FC-CM +). The proportion of patients with positive FC was higher than with CM (FC - 91.7%; CM - 63.9%). Thirty-five (48.6%) patients with meningeal infiltration had normal CSF cell count, normal total protein concentration, and normal lactate concentration. The proportion of cases in which these CSF parameters were normal did not differ according to the type of hematological neoplasm. The positivity of CM was significantly higher in patients with > 3 cell/mm
Identifiants
pubmed: 32519319
doi: 10.1007/s13760-020-01397-0
pii: 10.1007/s13760-020-01397-0
doi:
Substances chimiques
Biomarkers
0
Lactic Acid
33X04XA5AT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1543-1546Informations de copyright
© 2020. Belgian Neurological Society.
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