Effects of PPAR-γ agonists on oral cancer cell lines: Potential horizons for chemopreventives and adjunctive therapies.
15-deoxy-D12,14-prostaglandin J2 (15-PGJ2)
Ciglitazone
NF-κB
PPAR-γ
squamous cell carcinoma
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
06
01
2020
revised:
17
04
2020
accepted:
12
05
2020
pubmed:
11
6
2020
medline:
22
6
2021
entrez:
11
6
2020
Statut:
ppublish
Résumé
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) activators have anti-cancer effects. Our objective was to determine the effect of PPAR-γ ligands 15-deoxy-D NA and CA9-22 cells were treated in vitro with 15-PGJ MTT assays demonstrated dose-dependent decreases after 15-PGJ Our results suggest these agents, in addition to activating PPAR-γ, can downregulate NF-κB and potentiate apoptosis in oral cancer cells.
Sections du résumé
BACKGROUND
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) activators have anti-cancer effects. Our objective was to determine the effect of PPAR-γ ligands 15-deoxy-D
METHODS
NA and CA9-22 cells were treated in vitro with 15-PGJ
RESULTS
MTT assays demonstrated dose-dependent decreases after 15-PGJ
CONCLUSIONS
Our results suggest these agents, in addition to activating PPAR-γ, can downregulate NF-κB and potentiate apoptosis in oral cancer cells.
Identifiants
pubmed: 32519370
doi: 10.1002/hed.26286
pmc: PMC7657659
mid: NIHMS1621744
doi:
Substances chimiques
PPAR gamma
0
Prostaglandin D2
RXY07S6CZ2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2542-2554Subventions
Organisme : NCI NIH HHS
ID : P30 CA077598
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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