Peptide-Oleate Complexes Create Novel Membrane-Bound Compartments.

Artificial Cells / chemistry Cell Division Cytoplasmic Vesicles / chemistry Lactalbumin / chemistry Membranes / chemistry Oleic Acid / chemistry Peptides / chemistry
cell division giant unilamellar vesicles oleic acid peptides peptide–oleate complexes phospholipids protocells

Journal

Molecular biology and evolution
ISSN: 1537-1719
Titre abrégé: Mol Biol Evol
Pays: United States
ID NLM: 8501455

Informations de publication

Date de publication:
01 11 2020
Historique:
pubmed: 11 6 2020
medline: 15 4 2021
entrez: 11 6 2020
Statut: ppublish

Résumé

A challenging question in evolutionary theory is the origin of cell division and plausible molecular mechanisms involved. Here, we made the surprising observation that complexes formed by short alpha-helical peptides and oleic acid can create multiple membrane-enclosed spaces from a single lipid vesicle. The findings suggest that such complexes may contain the molecular information necessary to initiate and sustain this process. Based on these observations, we propose a new molecular model to understand protocell division.

Identifiants

DOI: 10.1093/molbev/msaa138 PMID: 32521018
pubmed: 32521018
pii: 5855678
doi: 10.1093/molbev/msaa138
doi:

Substances chimiques

Peptides 0
Oleic Acid 2UMI9U37CP
Lactalbumin 9013-90-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3083-3093

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Auteurs

Jesper S Hansen (JS)

Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden.
Experimental Medical Science, Medical Structural Biology, Lund University, Lund, Sweden.

Tuan Hiep Tran (TH)

Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden.

Michele Cavalera (M)

Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden.

Sanchari Paul (S)

Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden.

Arunima Chaudhuri (A)

Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden.

Karin Lindkvist-Petersson (K)

Experimental Medical Science, Medical Structural Biology, Lund University, Lund, Sweden.

James C S Ho (JCS)

Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden.
Centre for Biomimetic Sensor Science, School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.

Catharina Svanborg (C)

Department of Microbiology, Immunology and Glycobiology, Institute of Laboratory Medicine, Lund University, Lund, Sweden.

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Cellules artificielles › Peptide-Oleate Complexes Create Novel...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › Peptide-Oleate Complexes Create Novel...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Peptide-Oleate Complexes Create Novel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lactalbumine › Peptide-Oleate Complexes Create Novel...
questionsmedicales.fr › Tissus › Membranes › Peptide-Oleate Complexes Create Novel...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Acides oléiques › Acide oléique › Peptide-Oleate Complexes Create Novel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptide-Oleate Complexes Create Novel...