HMGB1-Neutralizing IgM Antibody Is a Normal Component of Blood Plasma.
Adult
Animals
Antibodies, Neutralizing
/ blood
Apolipoproteins E
/ genetics
Autoantibodies
/ blood
B-Lymphocyte Subsets
/ immunology
Cells, Cultured
Epitopes
/ immunology
Female
HMGB1 Protein
/ immunology
Humans
Immunoglobulin M
/ blood
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Receptors, Antigen, B-Cell
/ metabolism
Toll-Like Receptor 4
/ metabolism
Young Adult
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 07 2020
15 07 2020
Historique:
received:
07
01
2020
accepted:
10
05
2020
pubmed:
12
6
2020
medline:
16
3
2021
entrez:
12
6
2020
Statut:
ppublish
Résumé
Extracellular high-mobility group box 1 (HMGB1) is a prototypic damage-associated molecular pattern. Although a homeostatic level of extracellular HMGB1 may be beneficial for immune defense, tissue repair, and tissue regeneration, excessive HMGB1 is linked to inflammatory diseases. This prompts an intriguing question: how does a healthy body control the level of extracellular HMGB1? In this study, in the plasma of both healthy humans and healthy mice, we have identified an anti-HMGB1 IgM autoantibody that neutralizes extracellular HMGB1 via binding specifically to a 100% conserved epitope, namely HMW4 (HMGB1
Identifiants
pubmed: 32522835
pii: jimmunol.2000014
doi: 10.4049/jimmunol.2000014
pmc: PMC7416627
mid: NIHMS1598840
doi:
Substances chimiques
Antibodies, Neutralizing
0
Apolipoproteins E
0
Autoantibodies
0
Epitopes
0
HMGB1 Protein
0
Immunoglobulin M
0
Receptors, Antigen, B-Cell
0
Toll-Like Receptor 4
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
407-413Subventions
Organisme : NHLBI NIH HHS
ID : R21 HL106340
Pays : United States
Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.
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