[Ocrelizumab for treatment of multiple sclerosis].
Ocrelizumab zur Behandlung der Multiplen Sklerose.
B cell depleting monoclonal antibodies
B cells
Clinical neuroimmunology
Immunosuppression
Neuroinflammation
Journal
Der Nervenarzt
ISSN: 1433-0407
Titre abrégé: Nervenarzt
Pays: Germany
ID NLM: 0400773
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
pubmed:
12
6
2020
medline:
5
11
2020
entrez:
12
6
2020
Statut:
ppublish
Résumé
Ocrelizumab is a monoclonal antibody directed against the differentiation antigen CD20, which leads to an effective long-term depletion of lymphocytes, in particular B cells. Recently published phase 3 studies confirmed that ocrelizumab is effective in the treatment of both relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS). Based on these results, ocrelizumab was the first drug to be approved for primary chronic progressive MS. To place this therapeutic breakthrough in the context of the current MS therapeutic landscape, it is worthwhile taking a look back at the development of antibody-mediated CD20 depletion, the studies underlying the approval of ocrelizumab and their open extension phases. This review article discusses the available data on the efficacy and safety of long-term B‑cell depletion in MS patients and reviews current knowledge on the role of B‑lymphocytes in the immunopathogenesis of MS.
Identifiants
pubmed: 32524163
doi: 10.1007/s00115-020-00937-6
pii: 10.1007/s00115-020-00937-6
pmc: PMC7286209
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Immunologic Factors
0
ocrelizumab
A10SJL62JY
Types de publication
Journal Article
Review
Langues
ger
Sous-ensembles de citation
IM
Pagination
722-734Commentaires et corrections
Type : ErratumIn
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