Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020.
Betacoronavirus
/ genetics
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques
/ methods
Coronavirus Infections
/ diagnosis
Disease Outbreaks
Genome, Viral
/ genetics
Germany
/ epidemiology
Humans
Pandemics
Pneumonia, Viral
/ diagnosis
RNA-Directed DNA Polymerase
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
Whole Genome Sequencing
/ methods
COVID-19
Düsseldorf
Heinsberg
SARS-CoV-2
artic
genomic epidemiology
nanopore
superspreading
Journal
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
ISSN: 1560-7917
Titre abrégé: Euro Surveill
Pays: Sweden
ID NLM: 100887452
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
entrez:
12
6
2020
pubmed:
12
6
2020
medline:
19
6
2020
Statut:
ppublish
Résumé
We whole-genome sequenced 55 SARS-CoV-2 isolates from Germany to investigate SARS-CoV-2 outbreaks in 2020 in the Heinsberg district and Düsseldorf. While the genetic structure of the Heinsberg outbreak indicates a clonal origin, reflecting superspreading dynamics from mid-February during the carnival season, distinct viral strains were circulating in Düsseldorf in March, reflecting the city's international links. Limited detection of Heinsberg strains in the Düsseldorf area despite geographical proximity may reflect efficient containment and contact-tracing efforts.
Identifiants
pubmed: 32524946
doi: 10.2807/1560-7917.ES.2020.25.22.2000746
pmc: PMC7336109
doi:
Substances chimiques
RNA-Directed DNA Polymerase
EC 2.7.7.49
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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