Leucine-enriched amino acids maintain peripheral mTOR-Rheb localization independent of myofibrillar protein synthesis and mTORC1 signaling postexercise.

Amino Acids Amino Acids, Essential Humans Leucine Male Mechanistic Target of Rapamycin Complex 1 / metabolism Muscle, Skeletal / metabolism Ras Homolog Enriched in Brain Protein Resistance Training TOR Serine-Threonine Kinases
anabolic signaling essential amino acids leucine mTORC1 muscle protein synthesis

Journal

Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536

Informations de publication

Date de publication:
01 07 2020
Historique:
pubmed: 12 6 2020
medline: 24 6 2021
entrez: 12 6 2020
Statut: ppublish

Résumé

Postexercise protein ingestion can elevate rates of myofibrillar protein synthesis (MyoPS), mTORC1 activity, and mTOR translocation/protein-protein interactions. However, it is unclear if leucine-enriched essential amino acids (LEAA) can similarly facilitate intracellular mTOR trafficking in humans after exercise. The purpose of this study was to determine the effect of postexercise LEAA (4 g total EAAs, 1.6 g leucine) on acute MyoPS and mTORC1 translocation and signaling. Recreationally active men performed lower-body resistance exercise (5 × 8-10 leg press and leg extension) to volitional failure. Following exercise participants consumed LEAA (

Identifiants

DOI: 10.1152/japplphysiol.00241.2020 PMID: 32525432 PMC: PMC7469228
pubmed: 32525432
doi: 10.1152/japplphysiol.00241.2020
pmc: PMC7469228
doi:

Substances chimiques

Amino Acids 0
Amino Acids, Essential 0
RHEB protein, human 0
Ras Homolog Enriched in Brain Protein 0
MTOR protein, human EC 2.7.1.1
Mechanistic Target of Rapamycin Complex 1 EC 2.7.11.1
TOR Serine-Threonine Kinases EC 2.7.11.1
Leucine GMW67QNF9C

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

133-143

Références

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E753-64
pubmed: 12217893
Am J Physiol Cell Physiol. 2019 Dec 1;317(6):C1061-C1078
pubmed: 31461340
Nat Cell Biol. 2011 Apr;13(4):453-60
pubmed: 21394080
J Physiol. 1949 Aug;109(1-2):1-9
pubmed: 15394301
J Physiol. 2013 Jun 1;591(11):2911-23
pubmed: 23551944
J Physiol. 2009 Apr 1;587(Pt 7):1535-46
pubmed: 19188252
Am J Physiol Endocrinol Metab. 2010 May;298(5):E1011-8
pubmed: 20304764
J Physiol. 2014 Dec 15;592(24):5341-3
pubmed: 25512435
J Physiol. 2013 Sep 15;591(18):4611-20
pubmed: 23732640
Am J Clin Nutr. 2016 Oct;104(4):1014-1022
pubmed: 27604771
Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C537-C543
pubmed: 30133322
PLoS One. 2014 Feb 26;9(2):e89547
pubmed: 24586861
J Nutr. 2011 May;141(5):856-62
pubmed: 21430254
Front Nutr. 2019 Apr 11;6:40
pubmed: 31032258
Physiol Rep. 2018 Mar;6(5):
pubmed: 29512299
Am J Physiol Cell Physiol. 2017 Dec 1;313(6):C604-C611
pubmed: 28971834
Am J Clin Nutr. 2009 Jan;89(1):161-8
pubmed: 19056590
Anal Biochem. 2010 Jun 15;401(2):318-20
pubmed: 20206115
J Appl Physiol (1985). 2011 Jul;111(1):135-42
pubmed: 21527663
J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):57-62
pubmed: 25056502
Amino Acids. 2018 Jul;50(7):961-965
pubmed: 29725856
Front Physiol. 2017 Jun 07;8:390
pubmed: 28638350
Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C874-84
pubmed: 27053525
Muscle Nerve. 2011 May;43(5):717-25
pubmed: 21462204
J Physiol. 2012 Jun 1;590(11):2751-65
pubmed: 22451437
Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E822-9
pubmed: 19622785
J Appl Physiol (1985). 2009 May;106(5):1692-701
pubmed: 19036897
J Nutr Biochem. 1999 Feb;10(2):89-95
pubmed: 15539275
FASEB J. 2015 Oct;29(10):4358-73
pubmed: 26169935
Kidney Int Rep. 2018 Aug 17;3(6):1403-1415
pubmed: 30450467
J Appl Physiol (1985). 2014 Mar 1;116(5):504-13
pubmed: 24436296
Science. 2008 Jun 13;320(5882):1496-501
pubmed: 18497260
Appl Physiol Nutr Metab. 2013 Feb;38(2):120-5
pubmed: 23438221
Am J Clin Nutr. 2014 Jan;99(1):223S-230S
pubmed: 24284439
Nutrients. 2020 Apr 11;12(4):
pubmed: 32290521
Pflugers Arch. 2004 Feb;447(5):784-95
pubmed: 12845534
J Appl Physiol (1985). 2014 Jun 1;116(11):1353-64
pubmed: 24699854
Am J Clin Nutr. 2014 Jan;99(1):86-95
pubmed: 24257722
Exerc Sport Sci Rev. 2019 Jan;47(1):46-53
pubmed: 30334852
Clin Nutr. 2018 Dec;37(6 Pt A):2011-2021
pubmed: 29031484
Cell. 2010 Apr 16;141(2):290-303
pubmed: 20381137
Am J Clin Nutr. 2011 Sep;94(3):795-803
pubmed: 21795443
J Physiol. 2009 Feb 15;587(Pt 4):897-904
pubmed: 19124543
Am J Physiol. 1997 Jul;273(1 Pt 1):E122-9
pubmed: 9252488
Am J Clin Nutr. 2014 Feb;99(2):276-86
pubmed: 24284442
Clin Nutr. 2013 Apr;32(2):273-80
pubmed: 22889597
Am J Physiol. 1992 Mar;262(3 Pt 1):E372-6
pubmed: 1550230
Front Nutr. 2019 Jun 25;6:96
pubmed: 31294029
Cell Rep. 2014 Oct 9;9(1):1-8
pubmed: 25263562
Physiol Rep. 2017 Sep;5(18):
pubmed: 28963124
Appl Physiol Nutr Metab. 2007 Dec;32(6):1132-8
pubmed: 18059587
Br J Nutr. 2012 Nov 28;108(10):1780-8
pubmed: 22313809
Nutrients. 2016 Jun 28;8(7):
pubmed: 27367725
Am J Physiol. 1998 Jul;275(1):E73-8
pubmed: 9688876
Appl Physiol Nutr Metab. 2014 Feb;39(2):183-94
pubmed: 24476474
Nutrients. 2017 Dec 26;10(1):
pubmed: 29278358
FASEB J. 2005 Mar;19(3):422-4
pubmed: 15596483
Biochem Int. 1983 Jul;7(1):15-22
pubmed: 6383387
Sci Rep. 2017 Jul 10;7(1):5028
pubmed: 28694500
Amino Acids. 2010 May;38(5):1533-9
pubmed: 19882215
Am J Physiol. 1995 Mar;268(3 Pt 1):E514-20
pubmed: 7900797
Science. 2016 Jan 1;351(6268):43-8
pubmed: 26449471

Auteurs

Sarkis J Hannaian (SJ)

Faculty of Kinesiology and Physical Education, Department of Exercise Science, University of Toronto, Toronto, Canada.

Nathan Hodson (N)

Faculty of Kinesiology and Physical Education, Department of Exercise Science, University of Toronto, Toronto, Canada.
ORCID: 0000-0003-1330-4030

Sidney Abou Sawan (S)

Faculty of Kinesiology and Physical Education, Department of Exercise Science, University of Toronto, Toronto, Canada.

Michael Mazzulla (M)

Faculty of Kinesiology and Physical Education, Department of Exercise Science, University of Toronto, Toronto, Canada.

Hiroyuki Kato (H)

Technology Development Center, Institute of Food Sciences and Technologies, Ajinomoto Co., Inc., Kawasaki, Kanagawa, Japan.

Keiko Matsunaga (K)

Technology Development Center, Institute of Food Sciences and Technologies, Ajinomoto Co., Inc., Kawasaki, Kanagawa, Japan.

Marcus Waskiw-Ford (M)

Faculty of Kinesiology and Physical Education, Department of Exercise Science, University of Toronto, Toronto, Canada.

Justin Duncan (J)

Faculty of Kinesiology and Physical Education, Department of Exercise Science, University of Toronto, Toronto, Canada.

Dinesh A Kumbhare (DA)

Toronto Rehabilitation Institute, Toronto, Canada.
ORCID: 0000-0003-3889-7557

Daniel R Moore (DR)

Faculty of Kinesiology and Physical Education, Department of Exercise Science, University of Toronto, Toronto, Canada.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Leucine-enriched amino acids maintain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Leucine-enriched amino acids maintain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Leucine-enriched amino acids maintain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Leucine › Leucine-enriched amino acids maintain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-1 cible mécanistique de la rapamycine › Leucine-enriched amino acids maintain...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Leucine-enriched amino acids maintain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Protéine homologue de Ras enrichie dans le cerveau › Leucine-enriched amino acids maintain...
questionsmedicales.fr › Activités humaines › Exercice physique › Mise en condition physique de l'homme › Entraînement en résistance › Leucine-enriched amino acids maintain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Leucine-enriched amino acids maintain...