Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project.


Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
01 12 2020
Historique:
received: 19 10 2019
revised: 20 03 2020
accepted: 07 04 2020
pubmed: 12 6 2020
medline: 17 4 2021
entrez: 12 6 2020
Statut: ppublish

Résumé

A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/or vegetables intake were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age and the main known risk factors for gastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Exposure-response relations, including linear and nonlinear associations, were modeled using one- and two-order fractional polynomials. Gastric cancer risk was lower for a higher intake of fruits (OR: 0.76, 95% CI: 0.64-0.90), noncitrus fruits (OR: 0.86, 95% CI: 0.73-1.02), vegetables (OR: 0.68, 95% CI: 0.56-0.84), and fruits and vegetables (OR: 0.61, 95% CI: 0.49-0.75); results were consistent across sociodemographic and lifestyles categories, as well as study characteristics. Exposure-response analyses showed an increasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57-0.73 for six portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61-0.83 for six portions) and vegetables (OR: 0.51, 95% CI: 0.43-0.60 for 10 portions). A protective effect of all fruits, noncitrus fruits and vegetables was confirmed, supporting further dietary recommendations to decrease the burden of gastric cancer.

Identifiants

pubmed: 32525569
doi: 10.1002/ijc.33134
pmc: PMC8545605
mid: NIHMS1744713
doi:

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3090-3101

Subventions

Organisme : Intramural NIH HHS
ID : ZIA CP000185
Pays : United States

Informations de copyright

© 2020 UICC.

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Auteurs

Ana Ferro (A)

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Ana Rute Costa (AR)

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Samantha Morais (S)

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

Paola Bertuccio (P)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.

Matteo Rota (M)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Claudio Pelucchi (C)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Jinfu Hu (J)

Harbin Medical University, Harbin, China.

Kenneth C Johnson (KC)

School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Zuo-Feng Zhang (ZF)

Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson, Comprehensive Cancer Center, Los Angeles, California.

Domenico Palli (D)

Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy.

Monica Ferraroni (M)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Guo-Pei Yu (GP)

Medical Informatics Center, Peking University, Peking, China.

Rossella Bonzi (R)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Bárbara Peleteiro (B)

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

Lizbeth López-Carrillo (L)

Mexico National Institute of Public Health, Morelos, Mexico.

Shoichiro Tsugane (S)

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

Gerson Shigueaki Hamada (GS)

Nikkei Disease Prevention Center, São Paulo, Brazil.

Akihisa Hidaka (A)

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

Reza Malekzadeh (R)

Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

David Zaridze (D)

Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.

Dmitry Maximovich (D)

Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.

Jesus Vioque (J)

Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Department of Public Health, Miguel Hernandez University, FISABIO-ISABIAL, Alicante, Spain.

Eva M Navarrete-Muñoz (EM)

Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Department of Public Health, Miguel Hernandez University, FISABIO-ISABIAL, Alicante, Spain.

Juan Alguacil (J)

Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, Huelva, Spain.

Gemma Castaño-Vinyals (G)

Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Alicja Wolk (A)

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Niclas Håkansson (N)

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Raúl Ulises Hernández-Ramírez (RU)

Department of Biostatistics, Yale School of Public Health, Yale School of Medicine, New Haven, Connecticut.

Mohammadreza Pakseresht (M)

Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada.
Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK.

Mary H Ward (MH)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Farhad Pourfarzi (F)

Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.

Lina Mu (L)

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York.

Malaquias López-Cervantes (M)

Facultad de Medicina, UNAM, Coyoacán, Mexico.

Roberto Persiani (R)

Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Dipartimento di Chirurgia, Università Cattolica del Sacro Cuore, Roma, Italy.

Robert C Kurtz (RC)

Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York, New York.

Areti Lagiou (A)

Department of Public and Community Health, School of Health Sciences, University of West Attica, Egaleo, Greece.

Pagona Lagiou (P)

Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Paolo Boffetta (P)

The Tisch Cancer Institute, Department of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, New York.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

Stefania Boccia (S)

Sezione di Igiene, Dipartimento Universitario di Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Roma, Italy.
Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Eva Negri (E)

Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.

Maria Constanza Camargo (MC)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Maria Paula Curado (MP)

Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo, Brazil.

Carlo La Vecchia (C)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Nuno Lunet (N)

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

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