Bioengineering of Cytochrome P450 OleT

Bioengineering / methods Catalysis Catalytic Domain Cytochrome P-450 Enzyme System / chemistry Fatty Acids / chemistry Heme / chemistry Hydrogen Peroxide / chemistry Hydroxylation Molecular Dynamics Simulation Oxidation-Reduction Substrate Specificity
QM/MM methods bioengineering compound I density functional theory enzyme catalysis enzyme mechanism heme heme enzymes iron

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
09 Jun 2020
Historique:
received: 05 05 2020
revised: 29 05 2020
accepted: 04 06 2020
entrez: 13 6 2020
pubmed: 13 6 2020
medline: 13 2 2021
Statut: epublish

Résumé

The cytochromes P450 are versatile enzymes found in all forms of life. Most P450s use dioxygen on a heme center to activate substrates, but one class of P450s utilizes hydrogen peroxide instead. Within the class of P450 peroxygenases, the P450 OleT

Identifiants

DOI: 10.3390/molecules25112675 PMID: 32526971 PMC: PMC7321372
pubmed: 32526971
pii: molecules25112675
doi: 10.3390/molecules25112675
pmc: PMC7321372
pii:
doi:

Substances chimiques

Fatty Acids 0
Heme 42VZT0U6YR
Cytochrome P-450 Enzyme System 9035-51-2
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Fabián G Cantú Reinhard (FGC)

Manchester Institute of Biotechnology and Department of Chemical Engineering and Analytical Science, the University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

Yen-Ting Lin (YT)

Manchester Institute of Biotechnology and Department of Chemical Engineering and Analytical Science, the University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

Agnieszka Stańczak (A)

Manchester Institute of Biotechnology and Department of Chemical Engineering and Analytical Science, the University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
Faculty of Chemistry, Silesian University of Technology, 44-100 Gliwice, Poland.

Sam P de Visser (SP)

Manchester Institute of Biotechnology and Department of Chemical Engineering and Analytical Science, the University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.
ORCID: 0000-0002-2620-8788

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Lipides › Acides gras › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Métabolisme › Hydroxylation › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Bioengineering of Cytochrome P450 OleT
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Bioengineering of Cytochrome P450 OleT