Immediate effects of systemic administration of normal and high O
thoracic surgery
Journal
BMJ open respiratory research
ISSN: 2052-4439
Titre abrégé: BMJ Open Respir Res
Pays: England
ID NLM: 101638061
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
15
08
2019
revised:
10
12
2019
accepted:
30
12
2019
entrez:
13
6
2020
pubmed:
13
6
2020
medline:
11
6
2021
Statut:
ppublish
Résumé
Haemoglobin vesicles (HbVs) are red blood cell (RBC) substitutes with a phospholipid bilayer membrane and a polyethylene modified surface (diameter=250 nm; P Left pneumonectomy was performed under mechanical ventilation on rats, followed by rapid exsanguination of ~30% of the total circulating blood volume. Rat RBCs shed in 5% human serum albumin (HSA) solution (rat RBC), HbV with high oxygen affinity in 5% albumin solution (low-P Systemic arterial blood pressure significantly decreased after exsanguination and increased after each infusion. In the HbV, low-P The oxygen-carrying ability of HbV was comparable to that of rat RBCs, even under impaired lung function after pneumonectomy. HbVs with high oxygen affinity may have more beneficial effects on oxygenation in pulmonary resection.
Sections du résumé
BACKGROUND
Haemoglobin vesicles (HbVs) are red blood cell (RBC) substitutes with a phospholipid bilayer membrane and a polyethylene modified surface (diameter=250 nm; P
METHODS
Left pneumonectomy was performed under mechanical ventilation on rats, followed by rapid exsanguination of ~30% of the total circulating blood volume. Rat RBCs shed in 5% human serum albumin (HSA) solution (rat RBC), HbV with high oxygen affinity in 5% albumin solution (low-P
RESULTS
Systemic arterial blood pressure significantly decreased after exsanguination and increased after each infusion. In the HbV, low-P
CONCLUSIONS
The oxygen-carrying ability of HbV was comparable to that of rat RBCs, even under impaired lung function after pneumonectomy. HbVs with high oxygen affinity may have more beneficial effects on oxygenation in pulmonary resection.
Identifiants
pubmed: 32527871
pii: 7/1/e000476
doi: 10.1136/bmjresp-2019-000476
pmc: PMC7292042
pii:
doi:
Substances chimiques
Blood Substitutes
0
Drug Carriers
0
Hemoglobins
0
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: HS is an inventor on patents related to the production and utilisation of haemoglobin vesicles.
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