Circadian Clock Component Rev-erb

Animals Cell Line, Tumor Circadian Clocks / genetics Circadian Rhythm / genetics Down-Regulation E-Box Elements / genetics Gene Expression Regulation Glucuronides / metabolism Glucuronosyltransferase / genetics Injections, Intraperitoneal Male Mice Mice, Knockout Nuclear Receptor Subfamily 1, Group D, Member 1 / genetics Photoperiod Promoter Regions, Genetic Propofol / administration & dosage Transcription Factors / metabolism UDP-Glucuronosyltransferase 1A9

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
08 2020
Historique:
received: 25 03 2020
accepted: 23 04 2020
pubmed: 13 6 2020
medline: 14 9 2021
entrez: 13 6 2020
Statut: ppublish

Résumé

UDP-glucuronosyltransferases (UGTs) are a family of phase II enzymes that play an important role in metabolism and elimination of numerous endo- and xenobiotics. Here, we aimed to characterize diurnal rhythm of Ugt1a9 in mouse liver and to determine the molecular mechanisms underlying the rhythmicity. Hepatic Ugt1a9 mRNA and protein displayed robust diurnal rhythms in wild-type mice with peak levels at zeitgeber time (ZT) 6. Rhythmicity in Ugt1a9 expression was confirmed using synchronized Hepa-1c1c7 cells. We observed time-varying glucuronidation (ZT6 > ZT18) of propofol, a specific Ugt1a9 substrate, consistent with the diurnal pattern of Ugt1a9 protein. Loss of Rev-erb

Identifiants

DOI: 10.1124/dmd.120.000030 PMID: 32527940
pubmed: 32527940
pii: dmd.120.000030
doi: 10.1124/dmd.120.000030
doi:

Substances chimiques

Bhlhb3 protein, mouse 0
Glucuronides 0
Nr1d1 protein, mouse 0
Nuclear Receptor Subfamily 1, Group D, Member 1 0
Transcription Factors 0
Ugt1a9 protein, mouse 0
Glucuronosyltransferase EC 2.4.1.17
UDP-Glucuronosyltransferase 1A9 EC 2.4.1.17
Propofol YI7VU623SF

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

681-689

Informations de copyright

Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Haiman Xu (H)

Research Center for Biopharmaceutics and Pharmacokinetics (H.X., M.C., F.Y., T.Z., B.W.) and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE) (B.W.), College of Pharmacy, Jinan University, Guangzhou, China.

Min Chen (M)

Research Center for Biopharmaceutics and Pharmacokinetics (H.X., M.C., F.Y., T.Z., B.W.) and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE) (B.W.), College of Pharmacy, Jinan University, Guangzhou, China.

Fangjun Yu (F)

Research Center for Biopharmaceutics and Pharmacokinetics (H.X., M.C., F.Y., T.Z., B.W.) and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE) (B.W.), College of Pharmacy, Jinan University, Guangzhou, China.

Tianpeng Zhang (T)

Research Center for Biopharmaceutics and Pharmacokinetics (H.X., M.C., F.Y., T.Z., B.W.) and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE) (B.W.), College of Pharmacy, Jinan University, Guangzhou, China.

Baojian Wu (B)

Research Center for Biopharmaceutics and Pharmacokinetics (H.X., M.C., F.Y., T.Z., B.W.) and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE) (B.W.), College of Pharmacy, Jinan University, Guangzhou, China bj.wu@hotmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Circadian Clock Component Rev-erb
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Circadian Clock Component Rev-erb
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Horloges biologiques › Horloges circadiennes › Circadian Clock Component Rev-erb
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Rythme circadien › Circadian Clock Component Rev-erb
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Circadian Clock Component Rev-erb
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Éléments E-box › Circadian Clock Component Rev-erb
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Circadian Clock Component Rev-erb
questionsmedicales.fr › Glucides › Oses acides › Acides uroniques › Glucuronates › Glucuronides › Circadian Clock Component Rev-erb
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › Circadian Clock Component Rev-erb
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections péritoneales › Circadian Clock Component Rev-erb
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Circadian Clock Component Rev-erb
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Circadian Clock Component Rev-erb
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Membre-1 du groupe D de la sous-famille-1 de récepteurs nucléaires › Circadian Clock Component Rev-erb
questionsmedicales.fr › Phénomènes physiques › Temps › Photopériode › Circadian Clock Component Rev-erb
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Circadian Clock Component Rev-erb
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Propofol › Circadian Clock Component Rev-erb
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Circadian Clock Component Rev-erb
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › UDP-glucuronosyltransferase 1A9 › Circadian Clock Component Rev-erb