Gene editing in dermatology: Harnessing CRISPR for the treatment of cutaneous disease.
CRISPR
cutaneous disease
dermatology
gene editing
genodermatoses
viruses
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2020
2020
Historique:
accepted:
16
04
2020
entrez:
13
6
2020
pubmed:
13
6
2020
medline:
16
3
2021
Statut:
epublish
Résumé
The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system has revolutionized gene editing research. Through the repurposing of programmable RNA-guided CRISPR-associated (Cas) nucleases, CRISPR-based genome editing systems allow for the precise modification of specific sites in the human genome and inspire novel approaches for the study and treatment of inherited and acquired human diseases. Here, we review how CRISPR technologies have stimulated key advances in dermatologic research. We discuss the role of CRISPR in genome editing for cutaneous disease and highlight studies on the use of CRISPR-Cas technologies for genodermatoses, cutaneous viruses and bacteria, and melanoma. Additionally, we examine key limitations of current CRISPR technologies, including the challenges these limitations pose for the widespread therapeutic application of CRISPR-based therapeutics.
Identifiants
pubmed: 32528662
doi: 10.12688/f1000research.23185.1
pmc: PMC7265575
doi:
Types de publication
Journal Article
Review
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
281Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright: © 2020 Baker C and Hayden MS.
Déclaration de conflit d'intérêts
Competing interests: Hayden MS has received research funding from Excision Biotherapeutics.
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