Thromboxane A
Animals
Arterial Pressure
Disease Models, Animal
Male
Mechanoreceptors
/ drug effects
Mechanotransduction, Cellular
Muscle Contraction
Muscle, Skeletal
/ innervation
Peripheral Arterial Disease
/ drug therapy
Phenylacetates
/ pharmacology
Rats, Sprague-Dawley
Receptors, Prostaglandin E, EP4 Subtype
/ metabolism
Receptors, Thromboxane A2, Prostaglandin H2
/ antagonists & inhibitors
Reflex
/ drug effects
Sulfonamides
/ pharmacology
Time Factors
blood pressure
exercise pressor reflex
muscle afferents
sensory neurons
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
pubmed:
13
6
2020
medline:
8
10
2020
entrez:
13
6
2020
Statut:
ppublish
Résumé
The exercise pressor reflex is a feedback autonomic and cardiovascular control mechanism evoked by mechanical and metabolic signals within contracting skeletal muscles. The mechanically sensitive component of the reflex (the mechanoreflex) is exaggerated in patients with peripheral artery disease (PAD) and in a rat model of simulated PAD in which a femoral artery is chronically ligated. Products of cyclooxygenase enzyme activity have been shown to chronically sensitize the mechanoreflex in PAD, but the identity of the muscle afferent receptors that mediate the sensitization is unclear. We hypothesized that injection of the endoperoxide 4 receptor (EP4-R) antagonist L161982 or the thromboxane A
Identifiants
pubmed: 32530751
doi: 10.1152/ajpheart.00255.2020
pmc: PMC7473920
doi:
Substances chimiques
Phenylacetates
0
Ptger4 protein, rat
0
Receptors, Prostaglandin E, EP4 Subtype
0
Receptors, Thromboxane A2, Prostaglandin H2
0
Sulfonamides
0
daltroban
S25VDY08ZC
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
H320-H330Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL142877
Pays : United States
Organisme : NIH HHS
ID : HL-142877
Pays : United States
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