Enteroendocrine Dynamics - New Tools Reveal Hormonal Plasticity in the Gut.
differentiation
enteroendocrine
intestine
model systems
organoid
plasticity
Journal
Endocrine reviews
ISSN: 1945-7189
Titre abrégé: Endocr Rev
Pays: United States
ID NLM: 8006258
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
15
01
2020
accepted:
09
06
2020
pubmed:
13
6
2020
medline:
18
8
2021
entrez:
13
6
2020
Statut:
ppublish
Résumé
The recent intersection of enteroendocrine cell biology with single-cell technologies and novel in vitro model systems has generated a tremendous amount of new data. Here we highlight these recent developments and explore how these findings contribute to the understanding of endocrine lineages in the gut. In particular, the concept of hormonal plasticity, the ability of endocrine cells to produce different hormones over the course of their lifetime, challenges the classic notion of cell types. Enteroendocrine cells travel in the course of their life through different signaling environments that directly influence their hormonal repertoire. In this context, we examine how enteroendocrine cell fate is determined and modulated by signaling molecules such as bone morphogenetic proteins (BMPs) or location along the gastrointestinal tract. We analyze advantages and disadvantages of novel in vitro tools, adult stem cell or iPS-derived intestinal organoids, that have been crucial for recent findings on enteroendocrine development and plasticity. Finally, we illuminate the future perspectives of the field and discuss how understanding enteroendocrine plasticity can lead to new therapeutic approaches.
Identifiants
pubmed: 32531023
pii: 5856764
doi: 10.1210/endrev/bnaa018
pmc: PMC7320824
pii:
doi:
Substances chimiques
Hormones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Endocrine Society 2020.
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