An Autonomous Oscillation Times and Executes Centriole Biogenesis.
FCS
biological oscillator
biological timing
cell cycle
centriole
centriole duplication
centrosome
organelle biogenesis
organelle sizing
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
25 06 2020
25 06 2020
Historique:
received:
05
04
2019
revised:
19
12
2019
accepted:
08
05
2020
pubmed:
13
6
2020
medline:
22
1
2021
entrez:
13
6
2020
Statut:
ppublish
Résumé
The accurate timing and execution of organelle biogenesis is crucial for cell physiology. Centriole biogenesis is regulated by Polo-like kinase 4 (Plk4) and initiates in S-phase when a daughter centriole grows from the side of a pre-existing mother. Here, we show that a Plk4 oscillation at the base of the growing centriole initiates and times centriole biogenesis to ensure that centrioles grow at the right time and to the right size. The Plk4 oscillation is normally entrained to the cell-cycle oscillator but can run autonomously of it-potentially explaining why centrioles can duplicate independently of cell-cycle progression. Mathematical modeling indicates that the Plk4 oscillation can be generated by a time-delayed negative feedback loop in which Plk4 inactivates the interaction with its centriolar receptor through multiple rounds of phosphorylation. We hypothesize that similar organelle-specific oscillations could regulate the timing and execution of organelle biogenesis more generally.
Identifiants
pubmed: 32531200
pii: S0092-8674(20)30613-9
doi: 10.1016/j.cell.2020.05.018
pmc: PMC7327525
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
Drosophila Proteins
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
Sak protein, Drosophila
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1566-1581.e27Subventions
Organisme : Wellcome Trust
ID : 107457
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5255/A23225
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N016858/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104575
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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