Poor Adherence to Mediterranean Diet and Serum Lipopolysaccharide are Associated with Oxidative Stress in Patients with Non-Alcoholic Fatty Liver Disease.
Mediterranean diet
Non-alcoholic fatty liver disease
Nox2-derived peptide
lipopolysaccharide
oxidative stress
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 Jun 2020
10 Jun 2020
Historique:
received:
22
04
2020
revised:
05
06
2020
accepted:
07
06
2020
entrez:
14
6
2020
pubmed:
14
6
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Oxidative stress plays a pivotal role in non-alcoholic fatty liver disease (NAFLD). Factors inducing oxidative stress in NAFLD may be several; however, a relationship with the adherence to Mediterranean Diet (Med-diet) and with serum lipopolysaccharide (LPS) has been poorly investigated in this setting. The aim was to investigate factors associated with impaired oxidative stress in NAFLD, focusing on the potential role of LPS and Med-diet. We enrolled 238 consecutive outpatients from the PLINIO study, in whom we measured the soluble Nox2-derived peptide (sNox2-dp), a marker of systemic oxidative stress, and serum LPS. Adherence to Med-diet was investigated by a nine-item validated dietary questionnaire. Serum sNox2-dp and LPS were higher in patients with NAFLD compared to those without (25.0 vs. 9.0 pg/mL,
Identifiants
pubmed: 32531941
pii: nu12061732
doi: 10.3390/nu12061732
pmc: PMC7352324
pii:
doi:
Substances chimiques
Biomarkers
0
Lipopolysaccharides
0
NADPH Oxidase 2
EC 1.6.3.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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