Prostate Cancer Risk by BRCA2 Genomic Regions.
BRCA2
Genetic risk
Genomic region
Prospective cohort study
Prostate cancer
Prostate cancer cluster region
Journal
European urology
ISSN: 1873-7560
Titre abrégé: Eur Urol
Pays: Switzerland
ID NLM: 7512719
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
28
01
2020
accepted:
05
05
2020
pubmed:
14
6
2020
medline:
16
7
2021
entrez:
14
6
2020
Statut:
ppublish
Résumé
A BRCA2 prostate cancer cluster region (PCCR) was recently proposed (c.7914 to 3') wherein pathogenic variants (PVs) are associated with higher prostate cancer (PCa) risk than PVs elsewhere in the BRCA2 gene. Using a prospective cohort study of 447 male BRCA2 PV carriers recruited in the UK and Ireland from 1998 to 2016, we estimated standardised incidence ratios (SIRs) compared with population incidences and assessed variation in risk by PV location. Carriers of PVs in the PCCR had a PCa SIR of 8.33 (95% confidence interval [CI] 4.46-15.6) and were at a higher risk of PCa than carriers of other BRCA2 PVs (SIR = 3.31, 95% CI 1.97-5.57; hazard ratio = 2.34, 95% CI 1.09-5.03). PCCR PV carriers had an estimated cumulative PCa risk of 44% (95% CI 23-72%) by the age of 75 yr and 78% (95% CI 54-94%) by the age of 85 yr. Our results corroborate the existence of a PCCR in BRCA2 in a prospective cohort. PATIENT SUMMARY: In this report, we investigated whether the risk of prostate cancer for men with a harmful mutation in the BRCA2 gene differs based on where in the gene the mutation is located. We found that men with mutations in one region of BRCA2 had a higher risk of prostate cancer than men with mutations elsewhere in the gene.
Identifiants
pubmed: 32532514
pii: S0302-2838(20)30345-6
doi: 10.1016/j.eururo.2020.05.005
pmc: PMC7532700
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
494-497Subventions
Organisme : Cancer Research UK
ID : C12292/A20861
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C12292/A22820
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5047/A8385
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
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