The Mincle/Syk/NF-κB Signaling Circuit Is Essential for Maintaining the Protumoral Activities of Tumor-Associated Macrophages.
Aged
Animals
Cell Line, Tumor
Cytokines
/ immunology
Disease Models, Animal
Female
Humans
Lectins, C-Type
/ immunology
Lung Neoplasms
/ immunology
Macrophages
/ immunology
Male
Melanoma
/ immunology
Membrane Proteins
/ immunology
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, SCID
Middle Aged
NF-kappa B
/ immunology
Receptors, Immunologic
/ immunology
Signal Transduction
Syk Kinase
/ immunology
Tumor-Associated Macrophages
/ immunology
Journal
Cancer immunology research
ISSN: 2326-6074
Titre abrégé: Cancer Immunol Res
Pays: United States
ID NLM: 101614637
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
09
10
2019
revised:
08
04
2020
accepted:
04
06
2020
pubmed:
14
6
2020
medline:
20
1
2021
entrez:
14
6
2020
Statut:
ppublish
Résumé
Tumor-associated macrophages (TAM) have important roles in cancer progression, but the signaling behind the formation of protumoral TAM remains understudied. Here, by single-cell RNA sequencing, we revealed that the pattern recognition receptor Mincle was highly expressed in TAM and significantly associated with mortality in patients with non-small cell lung cancer. Cancer cells markedly induced Mincle expression in bone marrow-derived macrophages (BMDM), thus promoting cancer progression in invasive lung carcinoma LLC and melanoma B16F10
Identifiants
pubmed: 32532809
pii: 2326-6066.CIR-19-0782
doi: 10.1158/2326-6066.CIR-19-0782
doi:
Substances chimiques
CLEC4D protein, human
0
Clecsf8 protein, mouse
0
Cytokines
0
Lectins, C-Type
0
Membrane Proteins
0
NF-kappa B
0
Receptors, Immunologic
0
Syk Kinase
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1004-1017Informations de copyright
©2020 American Association for Cancer Research.