Endocannabinoid neuromodulation in the neostriatum decreases the GABAergic striato-nigral disinhibitory function and increases the nigro-collicular inhibitory pathway activity.
Anandamide
Caudate nucleus
Deep layers of superior colliculus
Putamen
Striatonigral-nigrotectal GABAergic pathways
Unconditioned fear
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
23
08
2019
accepted:
02
06
2020
pubmed:
14
6
2020
medline:
16
10
2021
entrez:
14
6
2020
Statut:
ppublish
Résumé
We previously reported the involvement of neostriato-nigral projections in the organisation of innate fear and panic attack-like responses organised by dorsal midbrain neurons, such as the periaqueductal grey matter and the deep layers of the superior colliculus (dlSC). In addition, several lines of evidence have demonstrated that cannabinoid receptor type 1 is found in the neostriatum (caudate nucleus and putamen; CPu). In the present study, we investigated the role of endocannabinoid neuromodulation in CPu in the expression of unconditioned fear-related behavioural responses elicited by microinjections of the γ-aminobutyric acid (GABA)
Identifiants
pubmed: 32533255
doi: 10.1007/s00702-020-02217-8
pii: 10.1007/s00702-020-02217-8
doi:
Substances chimiques
Endocannabinoids
0
Bicuculline
Y37615DVKC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM