Androgen action on renal calcium and phosphate handling: Effects of bisphosphonate treatment and low calcium diet.
Androgens
/ pharmacology
Animals
Bone Density
/ drug effects
Bone Resorption
/ metabolism
Bone and Bones
/ drug effects
Calcium
/ metabolism
Calcium, Dietary
/ pharmacology
Diet
Diphosphonates
/ pharmacology
Kidney
/ drug effects
Male
Mice
Mice, Inbred C57BL
Orchiectomy
Phosphates
/ metabolism
Urinalysis
Bone
Calcium
Orchidectomy
Phosphate
Testosterone
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
20 08 2020
20 08 2020
Historique:
received:
14
02
2020
revised:
05
05
2020
accepted:
03
06
2020
pubmed:
14
6
2020
medline:
3
6
2021
entrez:
14
6
2020
Statut:
ppublish
Résumé
Renal calcium and phosphate handling is an important contributor to mineral homeostasis and bone health and the androgen receptor (AR) is highly expressed in the kidney. We investigated the short term effects of androgen deprivation on renal calcium and phosphate reabsorption, independent of their effects on bone. Two weeks following orchidectomy (ORX) of adult mice, bone loss occurred along with hypercalciuria, which was similarly prevented by testosterone and dihydrotestosterone supplementation. Treatment with bisphosphonates prior to ORX also inhibited hypercalciuria, indicating that the calcium flux originated from the bone. Renal calcium and phosphate transporter expression was increased post-ORX, independent of bisphosphonates. Furthermore, androgen deprivation appeared to stimulate local synthesis of 1,25(OH)
Identifiants
pubmed: 32533994
pii: S0303-7207(20)30191-X
doi: 10.1016/j.mce.2020.110891
pii:
doi:
Substances chimiques
Androgens
0
Calcium, Dietary
0
Diphosphonates
0
Phosphates
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110891Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.