Glatiramer acetate increases T- and B -regulatory cells and decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) in an animal model of multiple sclerosis.
Animals
B-Lymphocytes, Regulatory
/ drug effects
Disease Models, Animal
Female
Glatiramer Acetate
/ pharmacology
Granulocyte-Macrophage Colony-Stimulating Factor
/ antagonists & inhibitors
Immunosuppressive Agents
/ pharmacology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Multiple Sclerosis
/ drug therapy
T-Lymphocytes, Regulatory
/ drug effects
B-regulatory cells (Bregs)
Experimental autoimmune encephalomyelitis
Glatiramer acetate (GA)
Granulocyte-macrophage colony-stimulating factor (GM-CSF)
Multiple sclerosis
T-regulatory cells (Tregs)
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 08 2020
15 08 2020
Historique:
received:
08
04
2020
revised:
21
05
2020
accepted:
26
05
2020
pubmed:
14
6
2020
medline:
11
11
2020
entrez:
14
6
2020
Statut:
ppublish
Résumé
To identify the mechanisms relevant for the therapeutic effect of glatiramer acetate (GA), we studied T- and B- regulatory cells as well as GM-CSF expression in mice recovered from experimental autoimmune encephalomyelitis (EAE). Selective depletion of Tregs reduced but did not eliminate the ability of GA to ameliorate EAE, indicating a role for additional immune-subsets. The prevalence of Bregs in the periphery and the CNS of EAE-mice increased following GA-treatment. Furthermore, GA downregulated the pathological expression of GM-CSF, on both the protein and mRNA levels. These findings corroborate the broad immunomodulatory mechanism of action of GA in EAE/MS.
Identifiants
pubmed: 32534388
pii: S0165-5728(20)30218-6
doi: 10.1016/j.jneuroim.2020.577281
pii:
doi:
Substances chimiques
Immunosuppressive Agents
0
Glatiramer Acetate
5M691HL4BO
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577281Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Rina Aharoni, Michael Sela, and Ruth Arnon received a research grant from Teva Pharmaceuticals.