Are lupus animal models useful for understanding and developing new therapies for human SLE?
Animals
Antibodies, Monoclonal, Humanized
/ pharmacology
B-Lymphocytes
/ drug effects
Disease Models, Animal
Drug Evaluation, Preclinical
/ methods
Drug Resistance
Feasibility Studies
Humans
Immunophenotyping
/ methods
Immunosuppressive Agents
/ pharmacology
Lupus Erythematosus, Systemic
/ blood
Mice
Rituximab
/ pharmacology
Autoimmunity
CyTOF
Murine SLE models
Systemic lupus erythematosus
Journal
Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
14
05
2020
accepted:
18
05
2020
pubmed:
15
6
2020
medline:
13
10
2021
entrez:
15
6
2020
Statut:
ppublish
Résumé
Systemic lupus erythematosus is a systemic autoimmune disease driven by a complex combination of genetic, environmental, and other immunoregulatory factors. The development of targeted therapies is complicated by heterogeneous clinical manifestations, varying organ involvement, and toxicity. Despite advances in understanding the mechanisms contributing to SLE, only one biologic drug, belimumab, is FDA-approved. The identification and development of potential therapies have largely been driven by studies in lupus animal models. Therefore, direct comparison of both the therapeutic and immunological findings in human and murine SLE studies is critical and can reveal important insights into indeed how useful and relevant are murine studies in SLE drug development. Studies involving belimumab, mycophenolate mofetil, abatacept, rituximab, and anti-interferon strategies generally demonstrated analogous findings in the attenuation of SLE manifestations and modulation of select immune cell populations in human and murine SLE. While further basic and translational studies are needed to identify SLE patient subsets likely to respond to particular therapeutic modalities and in dissecting complex mechanisms, we believe that despite some inherent weaknesses SLE mouse models will continue to be integral in developing targeted SLE therapies.
Identifiants
pubmed: 32535128
pii: S0896-8411(20)30108-6
doi: 10.1016/j.jaut.2020.102490
pmc: PMC7384952
mid: NIHMS1603245
pii:
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Immunosuppressive Agents
0
Rituximab
4F4X42SYQ6
belimumab
73B0K5S26A
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102490Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR048692
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR065594
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007288
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflict of interest to report.
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