The transitional phase of multiple sclerosis: Characterization and conceptual framework.
Biomarker
Disease course
Disease modifying therapy
Progressive multiple sclerosis
Trial design
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
01
03
2020
revised:
17
05
2020
accepted:
24
05
2020
pubmed:
15
6
2020
medline:
15
5
2021
entrez:
15
6
2020
Statut:
ppublish
Résumé
The conversion of relapsing-remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS) cannot be defined by a sharp threshold determined by event-based measures, but rather represents a gradual process. In consequence, there may exist a transitional phase between RRMS and clearly established SPMS. So far, transitional MS has been poorly characterized in terms of patient properties, course of disease and therapeutic interventions that may delay conversion to SPMS. Furthermore, the pathogenesis of transitional MS is incompletely understood, and no definitive imaging or laboratory test informs when exactly a patient has entered the transitional MS phase. Here we review the current knowledge and evidence characterizing the transitional phase of MS and propose potential designs and criteria for a prospective clinical study in patients with transitional MS.
Identifiants
pubmed: 32535501
pii: S2211-0348(20)30318-7
doi: 10.1016/j.msard.2020.102242
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102242Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.