Click chemistry compared to thiol chemistry for the synthesis of site-selective glycoconjugate vaccines using CRM
CRM197
Click chemistry
Conjugation chemistry
Glycoconjugate vaccine
O-antigen
Salmonella Typhimurium
Thiol chemistry
Journal
Glycoconjugate journal
ISSN: 1573-4986
Titre abrégé: Glycoconj J
Pays: United States
ID NLM: 8603310
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
02
2020
accepted:
30
05
2020
revised:
15
04
2020
pubmed:
15
6
2020
medline:
2
10
2021
entrez:
15
6
2020
Statut:
ppublish
Résumé
Conjugation chemistry is one of the main parameters affecting immunogenicity of glycoconjugate vaccines and a rational approach toward a deeper understanding of their mechanism of action will greatly benefit from highly-defined and well-characterized structures. Herein, different conjugation methods were investigated with the aim of controlling glycosylation site and glycosylation density on the carrier protein. S. Typhimurium lipopolysaccharide O-Antigen and CRM
Identifiants
pubmed: 32535667
doi: 10.1007/s10719-020-09930-2
pii: 10.1007/s10719-020-09930-2
pmc: PMC7501094
doi:
Substances chimiques
Bacterial Proteins
0
Carrier Proteins
0
Glycoconjugates
0
Lipopolysaccharides
0
O Antigens
0
Sulfhydryl Compounds
0
Vaccines
0
CRM197 (non-toxic variant of diphtheria toxin)
08VC9WC084
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
611-622Références
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