N-Substituted pyrimidinethione and acetophenone derivatives as a new therapeutic approach in diabetes.
Acetophenones
/ chemical synthesis
Diabetes Mellitus
/ drug therapy
Glycoside Hydrolase Inhibitors
/ chemical synthesis
Humans
Hypoglycemic Agents
/ chemical synthesis
Molecular Docking Simulation
Pyrimidines
/ chemical synthesis
Saccharomyces cerevisiae
/ enzymology
Structure-Activity Relationship
Thiones
/ chemical synthesis
N-substituted pyrimidinethione
acetophenone
diabetes mellitus
molecular docking
α-glycosidase
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
10
03
2020
revised:
17
05
2020
accepted:
22
05
2020
pubmed:
17
6
2020
medline:
11
6
2021
entrez:
16
6
2020
Statut:
ppublish
Résumé
In this study, compounds with 4-hydroxybutyl, 4-phenyl, 5-carboxylate, and pyrimidine moieties were determined as α-glycosidase inhibitors. N-Substituted pyrimidinethione and acetophenone derivatives (A1-A5, B1-B11, and C1-C11) were good inhibitors of the α-glycosidase enzyme, with K
Identifiants
pubmed: 32537841
doi: 10.1002/ardp.202000075
doi:
Substances chimiques
Acetophenones
0
Glycoside Hydrolase Inhibitors
0
Hypoglycemic Agents
0
Pyrimidines
0
Thiones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000075Informations de copyright
© 2020 Deutsche Pharmazeutische Gesellschaft.
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