Procalcitonin as a Marker of Comorbid Atrial Fibrillation in Chronic Kidney Disease and History of Sepsis.
atrial fibrillation
biomarkers
chronic kidney disease
hemodialysis
procalcitonin
sepsis
Journal
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
ISSN: 1938-2723
Titre abrégé: Clin Appl Thromb Hemost
Pays: United States
ID NLM: 9508125
Informations de publication
Date de publication:
Historique:
entrez:
17
6
2020
pubmed:
17
6
2020
medline:
2
2
2021
Statut:
ppublish
Résumé
Cardiovascular disease and infection are the leading causes of mortality in patients with stage 5 chronic kidney disease on hemodialysis (CKD5-HD). Inflammation is a large component in the pathogenesis of both atrial fibrillation (AF) and sepsis and may link these conditions in CKD5-HD. Procalcitonin (PCT) is an inflammatory biomarker elevated in systemic infection and CKD5-HD, yet its value with regard to comorbid AF has not been thoroughly investigated. The aim of this study sought to evaluate circulating inflammatory markers, including PCT, Angiopoietin-1, Angiopoetin-2, CD40-L, C-reactive protein, d-dimer, and von Willebrand factor in relation to these conditions. Plasma levels of inflammatory markers were measured by enzyme linked immunosorbent assay method in CKD5-HD (n = 97) patients and controls (n = 50). Procalcitonin levels were significantly elevated (
Identifiants
pubmed: 32539447
doi: 10.1177/1076029620932228
pmc: PMC7427007
doi:
Substances chimiques
Procalcitonin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1076029620932228Subventions
Organisme : NHLBI NIH HHS
ID : T35 HL120835
Pays : United States
Références
Lancet. 1993 Feb 27;341(8844):515-8
pubmed: 8094770
JAMA Netw Open. 2019 Aug 2;2(8):e198686
pubmed: 31390038
FEBS Lett. 1984 Feb 13;167(1):93-7
pubmed: 6546550
Intensive Care Med. 2003 Apr;29(4):579-83
pubmed: 12652350
Kidney Int. 2000 Oct;58(4):1758-64
pubmed: 11012910
Crit Care Med. 2008 Mar;36(3):941-52
pubmed: 18431284
Kidney Int. 2009 Aug;76(3):324-30
pubmed: 19494800
Inflamm Res. 2011 Feb;60(2):203-7
pubmed: 20953970
JAMA Intern Med. 2016 Sep 1;176(9):1266-76
pubmed: 27428731
Trends Immunol. 2006 Dec;27(12):552-8
pubmed: 17045842
Clin Appl Thromb Hemost. 2018 Dec;24(9_suppl):269S-276S
pubmed: 30370780
Am J Nephrol. 2011;34(4):330-6
pubmed: 21860228
BMC Emerg Med. 2015 Oct 14;15:30
pubmed: 26467100
Am J Kidney Dis. 2005 Nov;46(5):897-902
pubmed: 16253730
Nephrol Dial Transplant. 2001 May;16(5):975-9
pubmed: 11328903
Am J Kidney Dis. 2018 Mar;71(3 Suppl 1):A7
pubmed: 29477157
Crit Care Med. 2017 Feb;45(2):253-262
pubmed: 27632674
Clin Infect Dis. 2018 Aug 31;67(6):971-977
pubmed: 29668936