Blocking integrin α

Animals Antibodies, Monoclonal / immunology CD4-Positive T-Lymphocytes / immunology Cell Adhesion Molecules / antagonists & inhibitors Diet, Western / adverse effects Disease Models, Animal Gastrointestinal Microbiome / genetics Humans Integrins / antagonists & inhibitors Intestinal Mucosa / immunology Liver / immunology Male Mice Mice, Knockout Mucoproteins / antagonists & inhibitors Non-alcoholic Fatty Liver Disease / drug therapy RNA, Ribosomal, 16S / genetics Receptors, Cell Surface / deficiency
Epithelial barrier Gut permeability Inflammation Microbiota Non-alcoholic fatty liver disease

Journal

Journal of hepatology
ISSN: 1600-0641
Titre abrégé: J Hepatol
Pays: Netherlands
ID NLM: 8503886

Informations de publication

Date de publication:
11 2020
Historique:
received: 11 07 2019
revised: 29 04 2020
accepted: 25 05 2020
pubmed: 17 6 2020
medline: 14 10 2021
entrez: 17 6 2020
Statut: ppublish

Résumé

The heterodimeric integrin receptor α Male littermate F11r WD-fed knockout mice developed NASH and had increased hepatic and intestinal α These findings establish α Non-alcoholic steatohepatitis (NASH) is an advanced and progressive form of non-alcoholic fatty liver disease (NAFLD), and despite its growing incidence no therapies currently exist to halt NAFLD progression. Herein, we show that blocking integrin receptor α

Sections du résumé

BACKGROUND & AIMS
The heterodimeric integrin receptor α
METHODS
Male littermate F11r
RESULTS
WD-fed knockout mice developed NASH and had increased hepatic and intestinal α
CONCLUSIONS
These findings establish α
LAY SUMMARY
Non-alcoholic steatohepatitis (NASH) is an advanced and progressive form of non-alcoholic fatty liver disease (NAFLD), and despite its growing incidence no therapies currently exist to halt NAFLD progression. Herein, we show that blocking integrin receptor α

Identifiants

DOI: 10.1016/j.jhep.2020.05.047 PMID: 32540177 PMC: PMC7839272
pubmed: 32540177
pii: S0168-8278(20)30375-5
doi: 10.1016/j.jhep.2020.05.047
pmc: PMC7839272
mid: NIHMS1603613
pii:
doi:

Substances chimiques

Antibodies, Monoclonal 0
Cell Adhesion Molecules 0
F11r protein, mouse 0
Integrins 0
MADCAM1 protein, human 0
Madcam1 protein, mouse 0
Mucoproteins 0
RNA, Ribosomal, 16S 0
Receptors, Cell Surface 0
integrin alpha4beta7 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1013-1022

Subventions

Organisme : NIAID NIH HHS
ID : R03 AI138792
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK044234
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK062277
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK120531
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK072564
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK110264
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100287
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK061379
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111678
Pays : United States
Organisme : NIH HHS
ID : K01 OD023034
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204586
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI143454
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034933
Pays : United States

Informations de copyright

Copyright © 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details.

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Auteurs

Ravi P Rai (RP)

Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Yunshan Liu (Y)

Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.

Smita S Iyer (SS)

Center for Comparative Medicine, School of Veterinary Medicine, University of California, Davis, CA, USA; California National Primate Research Center, University of California, Davis, CA, USA; Department of Pathology, Microbiology, and Immunology, University of California, Davis, CA, USA.

Silvia Liu (S)

Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.

Biki Gupta (B)

Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Chirayu Desai (C)

Department of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Gujarat, India.

Pradeep Kumar (P)

Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.

Tekla Smith (T)

Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.

Aatur D Singhi (AD)

Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA; Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Asma Nusrat (A)

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

Charles A Parkos (CA)

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

Satdarshan P Monga (SP)

Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Mark J Czaja (MJ)

Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.

Frank A Anania (FA)

Division of Gastroenterology and Inborn Error Products, Food and Drug Administration, Silver Spring, MD, USA.

Reben Raeman (R)

Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: reben.raeman@pitt.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Blocking integrin α
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Blocking integrin α
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Blocking integrin α
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Blocking integrin α
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime occidental › Blocking integrin α
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Blocking integrin α
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Blocking integrin α
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Blocking integrin α
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Blocking integrin α
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Blocking integrin α
questionsmedicales.fr › Système digestif › Foie › Blocking integrin α
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Blocking integrin α
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Blocking integrin α
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Mucoprotéines › Blocking integrin α
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Blocking integrin α
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN ribosomique › ARN ribosomique 16S › Blocking integrin α
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Blocking integrin α