Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.
Analgesics, Opioid
/ adverse effects
Biomarkers
/ blood
Chronic Pain
/ blood
Education
/ methods
Humans
National Institutes of Health (U.S.)
/ trends
Neuroimaging
/ methods
Opioid Epidemic
/ prevention & control
Opioid-Related Disorders
/ blood
Pain Management
/ methods
Treatment Outcome
United States
Journal
Nature reviews. Neurology
ISSN: 1759-4766
Titre abrégé: Nat Rev Neurol
Pays: England
ID NLM: 101500072
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
accepted:
21
04
2020
pubmed:
17
6
2020
medline:
18
1
2022
entrez:
17
6
2020
Statut:
ppublish
Résumé
Pain medication plays an important role in the treatment of acute and chronic pain conditions, but some drugs, opioids in particular, have been overprescribed or prescribed without adequate safeguards, leading to an alarming rise in medication-related overdose deaths. The NIH Helping to End Addiction Long-term (HEAL) Initiative is a trans-agency effort to provide scientific solutions to stem the opioid crisis. One component of the initiative is to support biomarker discovery and rigorous validation in collaboration with industry leaders to accelerate high-quality clinical research into neurotherapeutics and pain. The use of objective biomarkers and clinical trial end points throughout the drug discovery and development process is crucial to help define pathophysiological subsets of pain, evaluate target engagement of new drugs and predict the analgesic efficacy of new drugs. In 2018, the NIH-led Discovery and Validation of Biomarkers to Develop Non-Addictive Therapeutics for Pain workshop convened scientific leaders from academia, industry, government and patient advocacy groups to discuss progress, challenges, gaps and ideas to facilitate the development of biomarkers and end points for pain. The outcomes of this workshop are outlined in this Consensus Statement.
Identifiants
pubmed: 32541893
doi: 10.1038/s41582-020-0362-2
pii: 10.1038/s41582-020-0362-2
pmc: PMC7326705
doi:
Substances chimiques
Analgesics, Opioid
0
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
381-400Subventions
Organisme : NCCIH NIH HHS
ID : K23 AT008477
Pays : United States
Organisme : NIGMS NIH HHS
ID : K23 GM111657
Pays : United States
Organisme : NIDA NIH HHS
ID : K24 DA029262
Pays : United States
Organisme : NINDS NIH HHS
ID : R61 NS113329
Pays : United States
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