Laboratory approach to investigation of anemia with a focus on pyruvate kinase deficiency.
anemia
pyruvate kinase deficiency
reticulocytes
Journal
International journal of laboratory hematology
ISSN: 1751-553X
Titre abrégé: Int J Lab Hematol
Pays: England
ID NLM: 101300213
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
23
01
2020
revised:
16
03
2020
accepted:
17
03
2020
entrez:
17
6
2020
pubmed:
17
6
2020
medline:
6
1
2021
Statut:
ppublish
Résumé
Anemia is a major health burden worldwide and affects approximately one-third of world's population. It is not a diagnosis; it is a manifestation of an underlying pathophysiology leading to either decreased hemoglobin (Hb), hematocrit (Hct), or red blood cells (RBCs). Iron deficiency anemia is still the most common cause of anemia worldwide. The symptoms are usually due to the underlying compensatory responses to decrease in oxygen delivery to the tissues. Laboratory investigation should start with complete blood count (CBC), reticulocyte count (RC), and peripheral smear evaluation. Further testing depends on these indices, that is, iron parameters and hemoglobinopathies/thalassemia evaluation in microcytic hypochromic anemia, vitamin B12, and folic acid level in macrocytic anemia. Increased RC denotes adequate bone marrow response and points toward hemolytic process and vice versa. Anemia diagnosis can be complex and confusing for the practicing physician. This review tries to give a practical simplistic approach to the diagnosis, focusing mainly on the basic parameters, that is, CBC, RC, and peripheral smear etc. Moreover, we have also tried to provide an update on the pyruvate kinase deficiency, as there has been recent exciting development in the management of these patients.
Substances chimiques
Hemoglobins
0
Folic Acid
935E97BOY8
Iron
E1UOL152H7
Pyruvate Kinase
EC 2.7.1.40
Vitamin B 12
P6YC3EG204
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107-112Informations de copyright
© 2020 John Wiley & Sons Ltd.
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