The Effect of Substituted Benzene-Sulfonamides and Clinically Licensed Drugs on the Catalytic Activity of CynT2, a Carbonic Anhydrase Crucial for
Anion Transport Proteins
/ antagonists & inhibitors
Anti-Bacterial Agents
/ chemistry
Benzene
/ chemistry
Carbon Dioxide
/ chemistry
Carbonic Anhydrase Inhibitors
/ chemistry
Carbonic Anhydrases
/ genetics
Drug Evaluation, Preclinical
/ methods
Escherichia coli Proteins
/ antagonists & inhibitors
Humans
Structure-Activity Relationship
Sulfonamides
/ chemistry
Escherichia coli
antibacterials
carbonic anhydrase
inhibitors
protonography
stopped-flow assay
sulfonamides
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Jun 2020
11 Jun 2020
Historique:
received:
22
05
2020
revised:
08
06
2020
accepted:
09
06
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
26
3
2021
Statut:
epublish
Résumé
Proteins are relevant antimicrobial drug targets, and among them, enzymes represent a significant group, since most of them catalyze reactions essential for supporting the central metabolism, or are necessary for the pathogen vitality. Genomic exploration of pathogenic and non-pathogenic microorganisms has revealed genes encoding for a superfamily of metalloenzymes, known as carbonic anhydrases (CAs, EC 4.2.1.1). CAs catalyze the physiologically crucial reversible reaction of the carbon dioxide hydration to bicarbonate and protons. Herein, we investigated the sulfonamide inhibition profile of the recombinant
Identifiants
pubmed: 32545297
pii: ijms21114175
doi: 10.3390/ijms21114175
pmc: PMC7312386
pii:
doi:
Substances chimiques
Anion Transport Proteins
0
Anti-Bacterial Agents
0
Carbonic Anhydrase Inhibitors
0
Escherichia coli Proteins
0
Sulfonamides
0
cyanate permease, E coli
0
Carbon Dioxide
142M471B3J
Carbonic Anhydrases
EC 4.2.1.1
can protein, E coli
EC 4.2.1.1
Benzene
J64922108F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
J Enzyme Inhib Med Chem. 2014 Oct;29(5):686-9
pubmed: 24156740
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
J Enzyme Inhib Med Chem. 2015 Apr;30(2):277-82
pubmed: 25007132
Drug Discov Today. 2018 Oct;23(10):1776-1783
pubmed: 29758342
Curr Top Med Chem. 2017;17(11):1237-1248
pubmed: 28049405
Metabolites. 2017 Nov 11;7(4):
pubmed: 29137134
Protein Sci. 2001 May;10(5):911-22
pubmed: 11316870
Biomed Res Int. 2014;2014:567929
pubmed: 25580435
J Enzyme Inhib Med Chem. 2019 Dec;34(1):1660-1667
pubmed: 31530039
Cell Calcium. 2019 Dec;84:102080
pubmed: 31589941
J Enzyme Inhib Med Chem. 2012 Dec;27(6):892-7
pubmed: 22803664
Bioorg Chem. 2018 Feb;76:281-287
pubmed: 29223031
Pathogens. 2017 Jul 15;6(3):
pubmed: 28714894
Nature. 2000 Jul 6;406(6791):64-7
pubmed: 10894541
Chem Rev. 2012 Aug 8;112(8):4421-68
pubmed: 22607219
J Bacteriol. 2003 Nov;185(21):6415-24
pubmed: 14563877
Nature. 1970 Aug 15;227(5259):680-5
pubmed: 5432063
J Bacteriol. 1994 Sep;176(18):5711-7
pubmed: 8083164
Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9828-33
pubmed: 27531955
Biochem J. 2016 Jul 15;473(14):2023-32
pubmed: 27407171
Orv Hetil. 2010 Dec 5;151(49):2003-10
pubmed: 21106480
Curr Top Med Chem. 2016;16(21):2359-68
pubmed: 27072694
Infect Immun. 2006 Mar;74(3):1649-60
pubmed: 16495536
Bioorg Med Chem. 2016 Aug 15;24(16):3413-7
pubmed: 27283786
J Enzyme Inhib Med Chem. 2020 Dec;35(1):255-260
pubmed: 31790601
Bioorg Med Chem. 2014 Jan 1;22(1):141-7
pubmed: 24332658
Bioorg Med Chem Lett. 2016 Apr 15;26(8):1941-6
pubmed: 26972117
Front Microbiol. 2012 Jan 19;3:9
pubmed: 22294983
Science. 1995 Oct 20;270(5235):397-403
pubmed: 7569993
ChemMedChem. 2016 Sep 6;11(17):1904-14
pubmed: 27304878
Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54
pubmed: 19846301
Bioorg Med Chem Lett. 2015 May 1;25(9):2002-6
pubmed: 25817590
Clin Microbiol Rev. 1998 Jan;11(1):142-201
pubmed: 9457432
Bioorg Med Chem. 2016 Mar 1;24(5):1115-20
pubmed: 26850377
Cold Spring Harb Symp Quant Biol. 2016;81:257-267
pubmed: 28057848
Curr Med Chem. 2015;22(18):2130-9
pubmed: 25312213
Nat Rev Drug Discov. 2008 Feb;7(2):168-81
pubmed: 18167490
Int J Mol Sci. 2019 May 17;20(10):
pubmed: 31108925
J Enzyme Inhib Med Chem. 2014 Jun;29(3):379-87
pubmed: 23627736
Curr Pharm Des. 2014;20(28):4535-48
pubmed: 24180404
Nat Rev Drug Discov. 2011 Sep 16;10(10):767-77
pubmed: 21921921
J Enzyme Inhib Med Chem. 2017 Dec;32(1):683-687
pubmed: 28274160
J Enzyme Inhib Med Chem. 2016;31(sup4):54-59
pubmed: 27615265
Bioorg Med Chem. 2016 Feb 15;24(4):835-40
pubmed: 26778292
Infect Genet Evol. 2011 Apr;11(3):654-62
pubmed: 21324381
Expert Opin Ther Pat. 2018 Oct;28(10):745-754
pubmed: 29973089
Front Oncol. 2018 Oct 04;8:423
pubmed: 30338242
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1060-1068
pubmed: 32314608
ACS Med Chem Lett. 2018 Sep 04;9(10):1035-1038
pubmed: 30344913
J Biol Chem. 1971 Apr 25;246(8):2561-73
pubmed: 4994926
ISME J. 2019 Aug;13(8):2094-2106
pubmed: 31024153
Bioorg Med Chem. 2015 Jul 1;23(13):3747-50
pubmed: 25910585
Nucleic Acids Res. 2018 Jan 4;46(D1):D413-D418
pubmed: 29106651
J Enzyme Inhib Med Chem. 2019 Dec;34(1):189-195
pubmed: 30734607
J Enzyme Inhib Med Chem. 2016 Dec;31(6):1254-60
pubmed: 27353388
Science. 1995 Jul 28;269(5223):496-512
pubmed: 7542800
J Enzyme Inhib Med Chem. 2015 Dec;30(6):920-4
pubmed: 25676328
Bioorg Med Chem. 2013 Aug 1;21(15):4521-5
pubmed: 23777827
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9072-7
pubmed: 20439758
J Enzyme Inhib Med Chem. 2012 Dec;27(6):759-72
pubmed: 22468747
Bioorg Med Chem. 2016 Sep 15;24(18):4410-4414
pubmed: 27480028
Expert Opin Drug Discov. 2017 Jan;12(1):61-88
pubmed: 27783541
Infect Immun. 2009 Sep;77(9):4111-20
pubmed: 19564378
J Enzyme Inhib Med Chem. 2015 Apr;30(2):325-32
pubmed: 24766661
Int J Med Microbiol. 2000 May;290(2):191-201
pubmed: 11045924
Mini Rev Med Chem. 2012 Nov;12(13):1404-18
pubmed: 22625412
J Enzyme Inhib Med Chem. 2016;31(3):345-60
pubmed: 26619898
J Enzyme Inhib Med Chem. 2014 Jun;29(3):449-55
pubmed: 23808803
J Enzyme Inhib Med Chem. 2016 Oct;31(5):689-94
pubmed: 26118417