Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 06 2020
16 06 2020
Historique:
received:
01
11
2019
accepted:
26
05
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
25
8
2020
Statut:
epublish
Résumé
Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.
Identifiants
pubmed: 32546718
doi: 10.1038/s41467-020-16765-w
pii: 10.1038/s41467-020-16765-w
pmc: PMC7297733
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3059Subventions
Organisme : Wellcome Trust
ID : 212219/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 213464/Z/18/Z
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1501/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102942/Z/13/A
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
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