Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
16 06 2020
Historique:
received: 01 11 2019
accepted: 26 05 2020
entrez: 18 6 2020
pubmed: 18 6 2020
medline: 25 8 2020
Statut: epublish

Résumé

Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.

Identifiants

pubmed: 32546718
doi: 10.1038/s41467-020-16765-w
pii: 10.1038/s41467-020-16765-w
pmc: PMC7297733
doi:

Substances chimiques

DNA, Mitochondrial 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3059

Subventions

Organisme : Wellcome Trust
ID : 212219/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 213464/Z/18/Z
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1501/2
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102942/Z/13/A
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

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Auteurs

Andrea Strakova (A)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Thomas J Nicholls (TJ)

Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.

Adrian Baez-Ortega (A)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Máire Ní Leathlobhair (M)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Alexander T Sampson (AT)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Katherine Hughes (K)

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Isobelle A G Bolton (IAG)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Kevin Gori (K)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Jinhong Wang (J)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Ilona Airikkala-Otter (I)

Worldwide Veterinary Service, International Training Center, Tamil Nadu, India.

Janice L Allen (JL)

Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.

Karen M Allum (KM)

World Vets, Gig Harbor, USA.

Clara L Arnold (CL)

Hopkins Belize Humane Society, Hopkins, Belize.

Leontine Bansse-Issa (L)

Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.

Thinlay N Bhutia (TN)

Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, Sikkim, India.

Jocelyn L Bisson (JL)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Kelli Blank (K)

Hopkins Belize Humane Society, Hopkins, Belize.

Cristóbal Briceño (C)

ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.

Artemio Castillo Domracheva (A)

Corozal Veterinary Hospital, University of Panamá, Panama City, Republic of Panama.

Anne M Corrigan (AM)

St. George's University, True Blue, Grenada.

Hugh R Cran (HR)

The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.

Jane T Crawford (JT)

Animal Medical Centre, Belize City, Belize.

Stephen M Cutter (SM)

Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.

Eric Davis (E)

International Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, USA.

Karina F de Castro (KF)

Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil.

Andrigo B De Nardi (AB)

School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, Brazil.

Anna P de Vos (AP)

Ladybrand Animal Clinic, Ladybrand, South Africa.

Laura Delgadillo Keenan (L)

Veterinary Clinic Sr. Dog's, Guadalajara, Mexico.

Edward M Donelan (EM)

Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.

Adela R Espinoza Huerta (AR)

World Vets Latin America Veterinary Training Center, Granada, Nicaragua.

Ibikunle A Faramade (IA)

National Veterinary Research Institute, Vom, Nigeria.

Mohammed Fazil (M)

Animal Clinic, Mombasa, Kenya.

Eleni Fotopoulou (E)

Intermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece.

Skye N Fruean (SN)

Animal Protection Society of Samoa, Apia, Samoa.

Fanny Gallardo-Arrieta (F)

Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.

Olga Glebova (O)

Veterinary Clinic BIOCONTROL, Moscow, Russia.

Pagona G Gouletsou (PG)

Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece.

Rodrigo F Häfelin Manrique (RF)

Veterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile.

Joaquim J G P Henriques (JJGP)

OnevetGroup, Hospital Veterinário Berna, Lisboa, Portugal.

Rodrigo S Horta (RS)

Universidade Vila Velha, Vila Velha, Brazil.

Natalia Ignatenko (N)

Veterinary Clinic Zoovetservis, Kiev, Ukraine.

Yaghouba Kane (Y)

École Inter-états des Sciences et Médecine Vétérinaires de Dakar, Dakar, Senegal.

Cathy King (C)

World Vets, Gig Harbor, USA.

Debbie Koenig (D)

World Vets, Gig Harbor, USA.

Ada Krupa (A)

Department of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Steven J Kruzeniski (SJ)

World Vets Latin America Veterinary Training Center, Granada, Nicaragua.

Marta Lanza-Perea (M)

St. George's University, True Blue, Grenada.

Mihran Lazyan (M)

Vetexpert Veterinary Group, Yerevan, Armenia.

Adriana M Lopez Quintana (AM)

Lopez Quintana Veterinary Clinic, Maldonado, Uruguay.

Thibault Losfelt (T)

Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France.

Gabriele Marino (G)

Department of Veterinary Sciences, University of Messina, Messina, Italy.

Simón Martínez Castañeda (S)

Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.

Mayra F Martínez-López (MF)

School of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.

Bedan M Masuruli (BM)

Veterinary Council of Tanzania, Dar-es-Salaam, Tanzania.

Michael Meyer (M)

Touray & Meyer Vet Clinic, Serrekunda, The Gambia.

Edward J Migneco (EJ)

Hillside Animal Hospital, St. Louis, USA.

Berna Nakanwagi (B)

The Kampala Veterinary Surgery, Kampala, Uganda.

Karter B Neal (KB)

Asavet Veterinary Charities, Tucson, USA.

Winifred Neunzig (W)

World Vets, Gig Harbor, USA.

Sally J Nixon (SJ)

Vets Beyond Borders, Bylakuppe, India.

Antonio Ortega-Pacheco (A)

Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.

Francisco Pedraza-Ordoñez (F)

Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.

Maria C Peleteiro (MC)

Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.

Katherine Polak (K)

Four Paws International, Vienna, Austria.

Ruth J Pye (RJ)

Vets Beyond Borders, The Rocks, Australia.

Juan C Ramirez-Ante (JC)

Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.

John F Reece (JF)

Help in Suffering, Jaipur, India.

Jose Rojas Gutierrez (J)

Veterinary Clinic Dr José Rojas, Los Andes, Chile.

Haleema Sadia (H)

Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.

Sheila K Schmeling (SK)

Corozal Veterinary Clinic, Corozal Town, Belize.

Olga Shamanova (O)

Veterinary Clinic Vetmaster, Ramenskoye, Russia.

Alan G Sherlock (AG)

Vets Beyond Borders, The Rocks, Australia.

Audrey E Steenland-Smit (AE)

Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.

Alla Svitich (A)

State Hospital of Veterinary Medicine, Kamianske, Ukraine.

Lester J Tapia Martínez (LJ)

World Vets Latin America Veterinary Training Center, Granada, Nicaragua.

Ismail Thoya Ngoka (I)

Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.

Cristian G Torres (CG)

Laboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.

Elizabeth M Tudor (EM)

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia.

Mirjam G van der Wel (MG)

Animal Anti Cruelty League, Port Elizabeth, South Africa.

Bogdan A Vițălaru (BA)

Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania.

Sevil A Vural (SA)

Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.

Oliver Walkinton (O)

Vets Beyond Borders, The Rocks, Australia.

Alvaro S Wehrle-Martinez (AS)

Faculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay.

Sophie A E Widdowson (SAE)

Lilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi.

Irina Zvarich (I)

Veterinary clinic Canine Heart, Yelizovo, Russia.

Patrick F Chinnery (PF)

MRC-Mitochondrial Biology Unit & Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Maria Falkenberg (M)

Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.

Claes M Gustafsson (CM)

Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.

Elizabeth P Murchison (EP)

Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. epm27@cam.ac.uk.

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