Physical deterioration and adaptive recovery in physically inactive breast cancer patients during adjuvant chemotherapy: a randomised controlled trial.
Adjuvants, Immunologic
/ therapeutic use
Adjuvants, Pharmaceutic
/ adverse effects
Adult
Breast
/ pathology
Breast Neoplasms
/ drug therapy
Cancer Survivors
Cardiorespiratory Fitness
/ physiology
Chemotherapy, Adjuvant
/ adverse effects
Exercise
/ physiology
Exercise Therapy
/ methods
Fatigue
/ etiology
Female
Humans
Middle Aged
Muscle Strength
/ physiology
Physical Fitness
/ physiology
Quality of Life
Sedentary Behavior
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 06 2020
16 06 2020
Historique:
received:
09
08
2019
accepted:
18
05
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Cardiorespiratory fitness is an independent risk factor for cardiovascular disease and shortened life expectancy in breast cancer survivors. This randomised controlled trial (n = 153) was designed for patients with a physically inactive lifestyle prediagnosis and concurrently referred to adjuvant chemotherapy. We compared two 12-week exercise interventions aimed at physiological and patient-reported outcomes (cardiorespiratory fitness, muscle strength, metabolic markers, physical activity, pain, fatigue), including a 39-week follow-up. A supervised hospital-based moderate to high intensity group exercise intervention was compared to an instructed home-based individual pedometer intervention. The two 12-week interventions included oncologists' recommendations and systematic health counselling. Outcomes were measured at baseline and week 6, 12 and 39. Primary outcome cardiorespiratory fitness declined significantly during chemotherapy and was restored in both interventions at follow-up. The interventions effectively engaged breast cancer patients in sustaining physical activities during and following adjuvant treatment. A composite metabolic score improved significantly. Positive cardiorespiratory fitness responders had improved clinical effects on fatigue, pain and dyspnoea versus negative responders. We conclude that a loss of cardiorespiratory fitness among physically inactive breast cancer patients may be restored by early initiated interventions and by adapting to physical activity recommendations, leading to a decreased cardiovascular risk profile in breast cancer survivors.
Identifiants
pubmed: 32546796
doi: 10.1038/s41598-020-66513-9
pii: 10.1038/s41598-020-66513-9
pmc: PMC7297957
doi:
Substances chimiques
Adjuvants, Immunologic
0
Adjuvants, Pharmaceutic
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9710Références
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