Inhibitory Effect of
Animals
Apigenin
/ chemistry
Coumaric Acids
/ chemistry
Cytochrome P-450 CYP3A
/ metabolism
Cytochrome P-450 CYP3A Inhibitors
/ chemistry
Dose-Response Relationship, Drug
Ferns
/ chemistry
Flavones
/ chemistry
Flavonoids
/ chemistry
Glycosides
Male
Medicine, Traditional
Molecular Structure
Plant Roots
/ chemistry
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
Lygodium root
drug–drug interactions
metabolism
midazolam
rat liver microsomes
Journal
Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
02
2020
accepted:
27
04
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
30
3
2021
Statut:
epublish
Résumé
The aim of the present study was to investigate the interactions of the main components of In vitro inhibition of drugs was assessed by incubating rat liver microsomes (RLMs) with a typical P450 3A enzyme substrate, midazolam, to determine their 50% inhibitory concentration (IC50) values. For the in vivo study, healthy male Sprague Dawley rats were consecutively administered acacetin or apigenin for 7 days at the dosage of 5 mg/kg after being randomly divided into 3 groups: Group A (control group), Group B (acacetin group) and Group C (apigenin group). Among the five main components of Acacetin and apigenin could inhibit the activity of the cytochrome P450 3A enzyme in vitro and in vivo, indicating that herbal drug interactions might occur when taking
Identifiants
pubmed: 32546958
doi: 10.2147/DDDT.S249308
pii: 249308
pmc: PMC7250706
doi:
Substances chimiques
Coumaric Acids
0
Cytochrome P-450 CYP3A Inhibitors
0
Flavones
0
Flavonoids
0
Glycosides
0
Apigenin
7V515PI7F6
Cyp3a2 protein, rat
EC 1.14.14.1
Cytochrome P-450 CYP3A
EC 1.14.14.1
p-coumaric acid
IBS9D1EU3J
acacetin
KWI7J0A2CC
diosmetin
TWZ37241OT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1909-1919Informations de copyright
© 2020 Zhou et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Biomed Chromatogr. 2015 Aug;29(8):1203-12
pubmed: 25582505
Eur J Pharmacol. 2015 Nov 5;766:99-105
pubmed: 26432689
Biochem Biophys Res Commun. 1996 Apr 5;221(1):157-62
pubmed: 8660328
Biochim Biophys Acta. 1995 Feb 21;1260(3):341-4
pubmed: 7873612
J Pharm Biomed Anal. 2015 Nov 10;115:368-74
pubmed: 26279368
Pharmacol Res. 2003 Nov;48(5):461-5
pubmed: 12967591
Food Chem. 2018 Jun 30;252:381-389
pubmed: 29478557
Xenobiotica. 2016;46(2):99-107
pubmed: 26207435
Arch Biochem Biophys. 2010 Sep 1;501(1):106-11
pubmed: 20361927
Adv Drug Deliv Rev. 2002 Nov 18;54(10):1271-94
pubmed: 12406645
J Pharm Pharm Sci. 2012;15(2):332-43
pubmed: 22579011
Eur J Clin Pharmacol. 2018 Jul;74(7):913-920
pubmed: 29572563
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):571-7
pubmed: 17350905
Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):875-94
pubmed: 17125407
J Clin Pharmacol. 2018 Sep;58(9):1205-1213
pubmed: 29663428
Acta Neurol Scand. 2008 Aug;118(2):69-86
pubmed: 18384456
Mol Cell Biol. 1986 Aug;6(8):2969-76
pubmed: 3785219
Arch Biochem Biophys. 1993 Dec;307(2):253-8
pubmed: 8274011
J Clin Pharmacol. 2015 Jan;55(1):56-62
pubmed: 25103957
J Nat Med. 2010 Jan;64(1):114-6
pubmed: 20091244
Epilepsy Behav. 2015 Aug;49:325-36
pubmed: 25817929
Pharmacol Rep. 2017 Oct;69(5):1044-1048
pubmed: 28939344
J Pharm Biomed Anal. 2015;111:131-7
pubmed: 25880244
Neurol India. 2006 Dec;54(4):354-8
pubmed: 17114841
J Cell Mol Med. 2015 Aug;19(8):1910-5
pubmed: 25856795
Front Pharmacol. 2012 Apr 30;3:69
pubmed: 22557968
J Pharm Biomed Anal. 2009 Dec 5;50(5):987-93
pubmed: 19664894
J Biol Chem. 1985 Jun 25;260(12):7435-41
pubmed: 3838989
Eur J Pharm Sci. 2017 Apr 1;101:80-89
pubmed: 28179134
J Cell Mol Med. 2002 Apr-Jun;6(2):189-98
pubmed: 12169204
J Agric Food Chem. 2014 May 28;62(21):4911-6
pubmed: 24815946
Pharm Res. 2017 Jul;34(7):1402-1415
pubmed: 28421306
Biomed Chromatogr. 2016 Jul;30(7):1145-1149
pubmed: 26525040
Xenobiotica. 2000 Dec;30(12):1131-52
pubmed: 11307970
Drug Metab Rev. 2009;41(3):408-21
pubmed: 19601720
J Pharm Biomed Anal. 2016 Feb 5;119:50-8
pubmed: 26641707
Drugs. 2009;69(13):1777-98
pubmed: 19719333
Clin Pharmacol Ther. 2004 Aug;76(2):99-103
pubmed: 15289786
Cell Physiol Biochem. 2014;34(4):1359-72
pubmed: 25301362
Biomed Res Int. 2013;2013:789184
pubmed: 24369535
Turk J Med Sci. 2015;45(4):919-24
pubmed: 26422868
Biol Pharm Bull. 2015;38(12):1910-7
pubmed: 26632182
Arch Pharm Res. 2011 Nov;34(11):1843-63
pubmed: 22139685
Cochrane Database Syst Rev. 2016 Nov 25;11:CD005146
pubmed: 27885664
Inflammation. 2013 Feb;36(1):169-76
pubmed: 22923003