TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy.
Adenosine Triphosphate
/ metabolism
Animals
Breast Neoplasms
/ drug therapy
Cell Line, Tumor
Doxorubicin
/ pharmacology
Drug Delivery Systems
/ methods
Drug Liberation
Drug Synergism
Female
Humans
Iron
/ chemistry
Mice
Nanoparticles
/ administration & dosage
Photothermal Therapy
/ methods
Tannins
/ chemistry
Topoisomerase II Inhibitors
/ pharmacology
Tumor Microenvironment
/ drug effects
Xenograft Model Antitumor Assays
adenosine triphosphate
anti-tumor therapy
chemosensitivity
multimodal imaging
responsive drug release
synergistic therapy
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
02
2020
accepted:
05
05
2020
entrez:
20
6
2020
pubmed:
20
6
2020
medline:
19
5
2021
Statut:
epublish
Résumé
Adenosine triphosphate (ATP), as a key substance for regulating tumor progression in the tumor microenvironemnt (TME), is an emerging target for tumor theranostics. Herein, we report a minimalist but versatile nanoplatform with simultaneously TME-responsive drug release, TME-enhanced imaging, ATP-depletion sensitized chemotherapy and photothermal therapy for intelligent tumor theranostics.
Identifiants
pubmed: 32550917
doi: 10.7150/thno.44569
pii: thnov10p6987
pmc: PMC7295044
doi:
Substances chimiques
Tannins
0
Topoisomerase II Inhibitors
0
Doxorubicin
80168379AG
Adenosine Triphosphate
8L70Q75FXE
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6987-7001Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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