[Collagen Peptides Improve Lymphocyte Distribution in Peripheral Blood and T Lymphocyte Proliferation in Spleen of Mice under the Condition of Simulated Weightlessness].

To investigate whether collagen peptides can improve the immune functions of mice under the condition of simulated weightlessness. Mouse tail-suspension model was used to simulate the effects of weightlessness. Tail-suspended mice were intraperitoneally injected with 600 mg collagen peptides per kilogram body weight once a day for 10 days. Then, the mice were killed, and white blood cells were counted and classified. Lymphocyte subsets and T lymphocyte proliferations in spleens were analyzed. Compared with normal control group, total and differential count of leukocytes, lymphocytes, T cells，CD4 Collagen peptides can effectively improve peripheral blood lymphocyte distributions and T lymphocyte proliferations of mice under the condition of simulated weightlessness. This study nay provid the experimental basis for improvement of immune functions of astronauts. 胶原蛋白肽改善模拟失重小鼠外周血淋巴细胞分布及脾脏T淋巴细胞增殖能力. 探讨胶原蛋白肽能否改善模拟失重小鼠的免疫功能. 采用尾吊法模拟失重小鼠模型，模拟失重小鼠每天1次腹腔注射600 mg/kg体重的胶原蛋白肽，10 d后处死小鼠，应用MTT法检测外周血白细胞分类和淋巴细胞亚群以及脾脏T淋巴细胞增殖能力. 与正常对照组相比，模拟失重组小鼠白细胞总数、淋巴细胞绝对值、T细胞、CD4 胶原蛋白肽能够有效改善模拟失重小鼠的外周血淋巴细胞分布及脾脏T淋巴细胞增殖能力.