Misidentification of unstable, low oxygen affinity hemoglobin variant.
Hemoglobin Louisville
Hemoglobin variant
Hemoglobinopathy
Journal
Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
21
05
2020
revised:
12
06
2020
accepted:
12
06
2020
pubmed:
20
6
2020
medline:
22
6
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
We present a case of Hemoglobin (Hgb) Louisville in a 6-y old girl presenting with hypoxia and mild hemolytic anemia. Hgb Louisville is a rare, unstable hemoglobin variant with low oxygen affinity, but initial workup of this case using widely-available hemoglobin fractionation methods was unable to differentiate this variant from normal hemoglobins. This resulted in a delayed diagnosis. This case highlights the limitations of routine hemoglobin fractionation methods for correct diagnosis of hemoglobin variants, and subsequent impact on patient care and management.
Sections du résumé
BACKGROUND
BACKGROUND
We present a case of Hemoglobin (Hgb) Louisville in a 6-y old girl presenting with hypoxia and mild hemolytic anemia.
METHODS
METHODS
Hgb Louisville is a rare, unstable hemoglobin variant with low oxygen affinity, but initial workup of this case using widely-available hemoglobin fractionation methods was unable to differentiate this variant from normal hemoglobins.
RESULTS
RESULTS
This resulted in a delayed diagnosis.
CONCLUSION
CONCLUSIONS
This case highlights the limitations of routine hemoglobin fractionation methods for correct diagnosis of hemoglobin variants, and subsequent impact on patient care and management.
Identifiants
pubmed: 32553722
pii: S0009-8981(20)30289-8
doi: 10.1016/j.cca.2020.06.023
pii:
doi:
Substances chimiques
Hemoglobins, Abnormal
0
Oxygen
S88TT14065
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
177-179Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.