Colchicine prevents atrial fibrillation promotion by inhibiting IL-1β-induced IL-6 release and atrial fibrosis in the rat sterile pericarditis model.
Animals
Anti-Arrhythmia Agents
/ pharmacology
Atrial Fibrillation
/ etiology
Atrial Remodeling
/ drug effects
Colchicine
/ pharmacology
Disease Models, Animal
Enzyme Activation
Fibrosis
Heart Atria
/ drug effects
Heart Rate
/ drug effects
Interleukin-1beta
/ metabolism
Interleukin-6
/ metabolism
JNK Mitogen-Activated Protein Kinases
/ metabolism
Male
NF-kappa B
/ metabolism
Pericarditis
/ complications
Phosphorylation
Proto-Oncogene Proteins c-akt
/ metabolism
Rats, Sprague-Dawley
Signal Transduction
p38 Mitogen-Activated Protein Kinases
/ metabolism
Atrial fibrillation
Atrial fibrosis
Colchicine
IL-1β
IL-6
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
28
03
2020
revised:
04
06
2020
accepted:
07
06
2020
pubmed:
20
6
2020
medline:
2
3
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
A few clinical trials have recently reported the potential effect of colchicine in preventing post-operative atrial fibrillation (POAF) and early atrial fibrillation (AF) recurrence after catheter pulmonary vein isolation. However, the molecular mechanisms through which colchicine inhibits AF remain unclear. We aim to assess the anti-AF effect of colchicine in the rat sterile pericarditis (SP) model and to investigate its molecular mechanisms. SP was induced in Sprague-Dawley rats by the epicardial application of sterile talc. Treatment with colchicine or vehicle began 1 d before pericardiotomy. AF was induced by transesophageal burst pacing on day 3 after surgery. Treatment with colchicine reduced the duration of AF and the probability of induction of AF in SP rats. The dose of 0.5 mg kg
Identifiants
pubmed: 32554248
pii: S0753-3322(20)30577-1
doi: 10.1016/j.biopha.2020.110384
pii:
doi:
Substances chimiques
Anti-Arrhythmia Agents
0
IL1B protein, rat
0
Il6 protein, rat
0
Interleukin-1beta
0
Interleukin-6
0
NF-kappa B
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
JNK Mitogen-Activated Protein Kinases
EC 2.7.11.24
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Colchicine
SML2Y3J35T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110384Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.