Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.
Afadin
CLPED1
Cleft palate
Nectin
Palatogenesis
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
13 07 2020
13 07 2020
Historique:
received:
10
02
2020
accepted:
02
06
2020
pubmed:
20
6
2020
medline:
29
12
2020
entrez:
20
6
2020
Statut:
epublish
Résumé
Cleft palate (CP), one of the most common congenital conditions, arises from failures in secondary palatogenesis during embryonic development. Several human genetic syndromes featuring CP and ectodermal dysplasia have been linked to mutations in genes regulating cell-cell adhesion, yet mouse models have largely failed to recapitulate these findings. Here, we use
Identifiants
pubmed: 32554531
pii: dev.189241
doi: 10.1242/dev.189241
pmc: PMC7375477
pii:
doi:
Substances chimiques
Microfilament Proteins
0
Nectins
0
afadin
0
Cre recombinase
EC 2.7.7.-
Integrases
EC 2.7.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDCR NIH HHS
ID : F31 DE026956
Pays : United States
Organisme : NIDCR NIH HHS
ID : K08 DE026537
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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