Meta-analysis of transcriptomic variation in T-cell populations reveals both variable and consistent signatures of gene expression and splicing.

Adult CD4-Positive T-Lymphocytes / physiology Cells, Cultured Cytokines / genetics Female Gene Expression / genetics Humans Male Middle Aged RNA Splicing / genetics T-Lymphocyte Subsets / physiology Transcriptome / genetics
T cells Th1 Th17 Th2 Treg alternative splicing transcriptomics

Journal

RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184

Informations de publication

Date de publication:
10 2020
Historique:
received: 15 04 2020
accepted: 12 06 2020
pubmed: 20 6 2020
medline: 6 10 2020
entrez: 20 6 2020
Statut: ppublish

Résumé

Human CD4

Identifiants

DOI: 10.1261/rna.075929.120 PMID: 32554554 PMC: PMC7491319
pubmed: 32554554
pii: rna.075929.120
doi: 10.1261/rna.075929.120
pmc: PMC7491319
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1320-1333

Subventions

Organisme : NIGMS NIH HHS
ID : F31 GM140978
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM128096
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM118048
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008216
Pays : United States

Informations de copyright

© 2020 Radens et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

Références

J Exp Med. 2007 Aug 6;204(8):1837-47
pubmed: 17635955
Bioinformatics. 2002;18 Suppl 1:S96-104
pubmed: 12169536
Genes Dev. 2015 Oct 1;29(19):2054-66
pubmed: 26443849
PLoS One. 2013 Nov 21;8(11):e81146
pubmed: 24363794
Cold Spring Harb Perspect Biol. 2018 Oct 1;10(10):
pubmed: 28847903
Science. 2002 Jan 11;295(5553):338-42
pubmed: 11786644
Nat Rev Immunol. 2016 Mar;16(3):149-63
pubmed: 26875830
Cell. 2013 Mar 14;152(6):1252-69
pubmed: 23498935
Nat Immunol. 2015 Mar;16(3):318-325
pubmed: 25621826
Am J Respir Cell Mol Biol. 2002 Feb;26(2):202-8
pubmed: 11804871
J Immunol. 2006 Jun 15;176(12):7768-74
pubmed: 16751425
Immunity. 2011 Dec 23;35(6):1010-22
pubmed: 22137454
Nat Rev Immunol. 2017 Sep;17(9):535-544
pubmed: 28555673
J Immunol. 2010 Jul 15;185(2):1071-81
pubmed: 20554955
J Exp Med. 2007 Jul 9;204(7):1509-17
pubmed: 17562814
Genome Biol. 2014;15(12):550
pubmed: 25516281
Cell Rep. 2016 Jun 21;15(12):2756-70
pubmed: 27292648
Nat Struct Mol Biol. 2015 Dec;22(12):968-75
pubmed: 26524494
Cell Cycle. 2017 Sep 17;16(18):1695-1704
pubmed: 28783414
J Biol Chem. 1997 Aug 22;272(34):21597-603
pubmed: 9261181
Science. 2012 Jul 27;337(6093):431-5
pubmed: 22837519
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17876-81
pubmed: 19805038
Retrovirology. 2015 Dec 10;12:102
pubmed: 26654242
Nat Biotechnol. 2014 Sep;32(9):903-14
pubmed: 25150838
Nat Immunol. 2007 May;8(5):457-62
pubmed: 17440451
J Immunol. 2007 Mar 15;178(6):3648-60
pubmed: 17339462
J Immunol. 2015 Oct 15;195(8):3642-53
pubmed: 26371251
RNA. 2012 May;18(5):1029-40
pubmed: 22454538
Hepatology. 2019 Sep;70(3):1011-1025
pubmed: 30637779
J Allergy Clin Immunol. 2016 Mar;137(3):907-18.e9
pubmed: 26431580
Science. 2014 May 9;344(6184):641-5
pubmed: 24812403
F1000Res. 2015 Dec 30;4:1521
pubmed: 26925227
J Allergy Clin Immunol. 2013 Oct;132(4):1005-8
pubmed: 23870669
RNA. 2007 Apr;13(4):563-72
pubmed: 17307815
Nucleic Acids Res. 2011 Jan;39(Database issue):D19-21
pubmed: 21062823
Cell Rep. 2018 Mar 6;22(10):2642-2653
pubmed: 29514093
Immunol Rev. 2013 May;253(1):216-36
pubmed: 23550649
Bioinformatics. 2011 Nov 1;27(21):2987-93
pubmed: 21903627
J Immunol. 2014 Oct 15;193(8):3959-65
pubmed: 25225667
J Biol Chem. 2014 Jan 24;289(4):2072-83
pubmed: 24324267
J Exp Med. 2014 Jan 13;211(1):89-104
pubmed: 24395888
Cell. 2019 Feb 7;176(4):882-896.e18
pubmed: 30639098
J Immunol. 2011 Dec 1;187(11):5615-26
pubmed: 22048764
PLoS One. 2017 Aug 1;12(8):e0181868
pubmed: 28763457
Oncotarget. 2016 Mar 22;7(12):13416-28
pubmed: 26967054
Cell. 1997 May 16;89(4):587-96
pubmed: 9160750
Genome Med. 2015 Nov 20;7:122
pubmed: 26589177
Scand J Immunol. 2003 Feb;57(2):192-8
pubmed: 12588667
Nature. 2013 Apr 25;496(7446):461-8
pubmed: 23467089
Genome Biol. 2017 Mar 15;18(1):51
pubmed: 28298237
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Cell Rep. 2016 Dec 20;17(12):3206-3218
pubmed: 28009290
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7061-6
pubmed: 26038559
Cell Rep. 2019 Feb 5;26(6):1627-1640.e7
pubmed: 30726743
Immunol Rev. 2014 Sep;261(1):23-49
pubmed: 25123275
J Clin Invest. 2009 Mar;119(3):565-72
pubmed: 19188681
Epigenetics. 2015;10(1):6-18
pubmed: 25494542
Genes Immun. 2005 Aug;6(5):398-406
pubmed: 15889130
Biol Direct. 2015 Apr 03;10:14
pubmed: 25886751
Elife. 2016 Feb 01;5:e11752
pubmed: 26829591
Sci Immunol. 2019 Jan 18;4(31):
pubmed: 30658968
J Immunol. 2012 Oct 15;189(8):3947-56
pubmed: 22988034
Nat Methods. 2017 Apr;14(4):417-419
pubmed: 28263959
J Immunol. 2010 Apr 1;184(7):3433-41
pubmed: 20181882
J Exp Med. 2000 Jul 17;192(2):303-10
pubmed: 10899917
Elife. 2019 Mar 12;8:
pubmed: 30860479
Nat Immunol. 2008 Apr;9(4):353-9
pubmed: 18349815
Cell Rep. 2017 Dec 26;21(13):3885-3899
pubmed: 29281835
Hum Immunol. 2016 Feb;77(2):201-13
pubmed: 26686412
Nat Immunol. 2005 Nov;6(11):1123-32
pubmed: 16200070
Cell. 2006 Sep 22;126(6):1121-33
pubmed: 16990136
Nat Immunol. 2016 Aug;17(8):976-84
pubmed: 27376469

Auteurs

Caleb M Radens (CM)

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Davia Blake (D)

Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Paul Jewell (P)

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Department of Computer Science, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Yoseph Barash (Y)

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Department of Computer Science, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Kristen W Lynch (KW)

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Meta-analysis of transcriptomic variation in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Meta-analysis of transcriptomic variation in...
questionsmedicales.fr › Cellules › Cellules cultivées › Meta-analysis of transcriptomic variation in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Meta-analysis of transcriptomic variation in...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Meta-analysis of transcriptomic variation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Meta-analysis of transcriptomic variation in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Meta-analysis of transcriptomic variation in...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Meta-analysis of transcriptomic variation in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Meta-analysis of transcriptomic variation in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Meta-analysis of transcriptomic variation in...