Usefulness of hemoglobin examination in gingival crevicular fluid during supportive periodontal therapy to diagnose the pre-symptomatic state in periodontal disease.
Gingival crevicular fluid
Hemoglobin
Periodontitis
Supportive periodontal therapy
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
24
01
2020
accepted:
05
06
2020
pubmed:
20
6
2020
medline:
26
1
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
The absence of bleeding on probing (BOP) is a good predictor of disease stability. This study investigated whether detection of hemoglobin (Hb) in gingival crevicular fluid (GCF) indicates minute signs of periodontal disease, even in BOP (-) cases. GCF was collected from gingival sulci of 152 sound maxillary and mandibular teeth from 76 patients who had entered supportive periodontal therapy (SPT) using the split-mouth design. As clinical parameters, plaque index, GCF amount, gingival index, probing depth (PD), clinical attachment level, BOP, and alveolar bone resorption ratio were then recorded. As biochemical parameters, Hb amount, alkaline phosphatase (ALP) activity, and protein amount in GCF were measured. Periodontal conditions of diseased sites (PD ≥ 4 mm, BOP (+)) and healthy sites (PD ≤ 4 mm, BOP (-)) were further classified into two groups using the Hb cutoff value determined by PD and BOP and analyzed. Despite being healthy, ALP activity and protein amount in sulci of the group with Hb level greater than the cutoff value were significantly higher than those in the group with Hb level less than the cutoff value (P < 0.01). This study indicates that Hb examination is a promising candidate marker of pre-symptomatic periodontal disease because Hb presence in GCF suggests slight tissue damage, even in healthy sites defined as BOP (-). Hb examination of GCF is a powerful diagnostic tool for pre-symptomatic diagnosis of periodontal disease.
Identifiants
pubmed: 32556661
doi: 10.1007/s00784-020-03396-0
pii: 10.1007/s00784-020-03396-0
pmc: PMC7819911
doi:
Substances chimiques
Hemoglobins
0
Types de publication
Journal Article
Langues
eng
Pagination
487-495Subventions
Organisme : The Ministry of Education and Science Research Funds
ID : 20K09964
Organisme : The Ministry of Education and Science Research Funds
ID : 20K09981
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