A Novel Compound YS-5-23 Exhibits Neuroprotective Effect by Reducing β-Site Amyloid Precursor Protein Cleaving Enzyme 1's Expression and H
Amyloid Precursor Protein Secretases
/ antagonists & inhibitors
Antioxidants
/ pharmacology
Aspartic Acid Endopeptidases
/ antagonists & inhibitors
Cell Line, Tumor
Coumaric Acids
/ pharmacology
Flavones
/ pharmacology
HEK293 Cells
Humans
Hydrogen Peroxide
/ pharmacology
Membrane Potential, Mitochondrial
/ drug effects
Mitochondria
/ drug effects
Neuroprotective Agents
/ pharmacology
Oxidative Stress
/ drug effects
Phosphatidylinositol 3-Kinases
/ metabolism
Protease Inhibitors
/ pharmacology
Proto-Oncogene Proteins c-akt
/ metabolism
Signal Transduction
/ drug effects
Alzheimer’s disease
BACE1
Oxidative stress
PI3K/Akt
Journal
Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
16
03
2020
accepted:
12
06
2020
revised:
08
06
2020
pubmed:
20
6
2020
medline:
9
6
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
The abnormally accumulated amyloid-β (Aβ) and oxidative stress contribute to the initiation and progression of Alzheimer's disease (AD). β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme for the production of Aβ. Furthermore, Aβ was reported to increase oxidative stress; then the overproduced oxidative stress continues to increase the expression and activity of BACE1. Consequently, inhibition of both BACE1 and oxidative stress is a better strategy for AD therapy compared with those one-target treatment methods. In the present study, our novel small molecule YS-5-23 was proved to possess both of the activities. Specifically, we found that YS-5-23 reduces BACE1's expression in both SH-SY5Y and Swedish mutated amyloid precursor protein (APP) overexpressed HEK293 cells, and it can also suppress BACE1's expression induced by H
Identifiants
pubmed: 32556702
doi: 10.1007/s11064-020-03073-4
pii: 10.1007/s11064-020-03073-4
doi:
Substances chimiques
Antioxidants
0
Coumaric Acids
0
Flavones
0
Neuroprotective Agents
0
Protease Inhibitors
0
Hydrogen Peroxide
BBX060AN9V
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Amyloid Precursor Protein Secretases
EC 3.4.-
Aspartic Acid Endopeptidases
EC 3.4.23.-
BACE1 protein, human
EC 3.4.23.46
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2113-2127Subventions
Organisme : National Natural Science Foundation of China
ID : 31870786
Organisme : National Natural Science Foundation of China
ID : 31371331
Organisme : National Natural Science Foundation of China
ID : 81273406
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