A Double-Edged Sword-Cardiovascular Concerns of Potential Anti-COVID-19 Drugs.
COVID-19
Complications
Potential cardiotoxicity
SARS-CoV-2
Journal
Cardiovascular drugs and therapy
ISSN: 1573-7241
Titre abrégé: Cardiovasc Drugs Ther
Pays: United States
ID NLM: 8712220
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
accepted:
08
06
2020
pubmed:
20
6
2020
medline:
7
4
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 significantly affects multiple systems including the cardiovascular system. Most importantly, in addition to the direct injury from the virus per se, the subsequent cytokine storm, an overproduction of immune cells and their activating compounds, causes devastating damage. To date, emerging anti-SARS-CoV-2 treatments are warranted to control epidemics. Several candidate drugs have been screened and are currently under investigation. These primarily include antiviral regimens and immunomodulatory regimens. However, beyond the anti-SARS-CoV-2 effects, these drugs may also have risks to the cardiovascular system, especially altering cardiac conduction. Herein, we review the cardiovascular risks of potential anti-COVID-19 drugs.
Identifiants
pubmed: 32557011
doi: 10.1007/s10557-020-07024-7
pii: 10.1007/s10557-020-07024-7
pmc: PMC7297930
doi:
Substances chimiques
Antiviral Agents
0
Immunologic Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-214Références
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