A systematic review and trial sequential analysis of intravenous vs. oral peri-operative paracetamol.
acetaminophen
cost-benefit analysis
meta-analysis
paracetamol
postoperative pain
systematic review
Journal
Anaesthesia
ISSN: 1365-2044
Titre abrégé: Anaesthesia
Pays: England
ID NLM: 0370524
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
accepted:
25
05
2020
pubmed:
20
6
2020
medline:
16
1
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Postoperative pain might be different after intravenous vs. oral paracetamol. We systematically reviewed randomised controlled trials in patients >15 years that compared intravenous with oral paracetamol for postoperative pain. We identified 14 trials with 1695 participants. There was inconclusive evidence for an effect of route of paracetamol administration on postoperative pain at 0-2 h (734 participants), 2-6 h (766 participants), 6-24 h (1115 participants) and >24 h (248 participants), with differences in standardised mean (95%CI) pain scores for intravenous vs. oral of -0.17 (-0.45 to 0.10), -0.09 (-0.24 to 0.06), 0.06 (-0.12 to 0.23) and 0.03 (-0.22 to 0.28), respectively. Trial sequential analyses suggested that a total of 3948 participants would be needed to demonstrate a meaningful difference in pain or its absence at 0-2 h. There were no differences in secondary outcomes. Intravenous paracetamol is more expensive than oral paracetamol. Substitution of oral paracetamol in half the patients given intravenous paracetamol in our hospital would save around £ 38,711 (€ 43,960 or US$ 47,498) per annum.
Identifiants
pubmed: 32557588
doi: 10.1111/anae.15163
pmc: PMC7818191
doi:
Substances chimiques
Analgesics, Non-Narcotic
0
Acetaminophen
362O9ITL9D
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
270-276Subventions
Organisme : Universidad del Cauca
Organisme : Erasmus Medisch Centrum
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.
Références
J Arthroplasty. 2017 Apr;32(4):1125-1127
pubmed: 27839957
Anaesthesia. 2009 Jan;64(1):65-72
pubmed: 19087009
BMJ Open. 2016 Aug 12;6(8):e011890
pubmed: 27519923
Reg Anesth Pain Med. 2019 May;44(5):565-572
pubmed: 30867279
Eur Arch Otorhinolaryngol. 2008 Mar;265(3):351-5
pubmed: 17891409
Anesthesiology. 2012 Feb;116(2):248-73
pubmed: 22227789
Anesth Analg. 2003 Aug;97(2):534-40, table of contents
pubmed: 12873949
World J Surg. 2010 Mar;34(3):521-6
pubmed: 20054544
Br J Clin Pharmacol. 2019 Jan;85(1):126-135
pubmed: 30321459
J Arthroplasty. 2017 Oct;32(10):3029-3033
pubmed: 28690041
J Palliat Med. 2016 Feb;19(2):231-2
pubmed: 26840859
Pain Med. 2017 Dec 1;18(12):2466-2473
pubmed: 28034981
Anesthesiology. 2005 Apr;102(4):822-31
pubmed: 15791113
Curr Ther Res Clin Exp. 2005 Jul;66(4):294-306
pubmed: 24936118
Acta Anaesthesiol Scand. 2004 Aug;48(7):867-70
pubmed: 15242431
Anesthesiology. 2000 Oct;93(4):1123-33
pubmed: 11020770
Int J Clin Pharmacol Ther. 2004 Jan;42(1):50-7
pubmed: 14756388
Anaesth Intensive Care. 2011 Mar;39(2):242-6
pubmed: 21485673
Br J Anaesth. 2005 May;94(5):642-8
pubmed: 15790675
Cochrane Database Syst Rev. 2016 May 23;(5):CD007126
pubmed: 27213715
BMC Med Res Methodol. 2014 Dec 19;14:135
pubmed: 25524443
Br J Anaesth. 2013 Mar;110(3):432-7
pubmed: 23220855
J Cardiothorac Vasc Anesth. 2005 Jun;19(3):306-9
pubmed: 16130055
Am J Health Syst Pharm. 2018 Mar 15;75(6):367-375
pubmed: 29523533
Anesth Essays Res. 2017 Jul-Sep;11(3):594-598
pubmed: 28928554
Anaesth Intensive Care. 2012 Jan;40(1):166-71
pubmed: 22313079
Paediatr Anaesth. 2005 Aug;15(8):663-70
pubmed: 16029401
Anesthesiol Clin. 2010 Dec;28(4):619-45
pubmed: 21074742
Pain Med. 2019 Aug 1;20(8):1584-1591
pubmed: 30561704
Laryngoscope Investig Otolaryngol. 2020 Apr 16;5(3):348-353
pubmed: 32596476
Medicine (Baltimore). 2018 Feb;97(6):e9751
pubmed: 29419667
J Arthroplasty. 2019 Jul;34(7S):S215-S220
pubmed: 30948288
Pharmacotherapy. 2012 Jun;32(6):559-79
pubmed: 22570116
J Clin Epidemiol. 2013 Jul;66(7):726-35
pubmed: 23570745
Anaesth Intensive Care. 1987 Feb;15(1):68-71
pubmed: 2882705
Surg Laparosc Endosc Percutan Tech. 2009 Aug;19(4):321-3
pubmed: 19692881
Can J Hosp Pharm. 2015 May-Jun;68(3):238-47
pubmed: 26157186
J Clin Anesth. 2020 May;61:109628
pubmed: 31669049
Am J Ther. 2013 Mar-Apr;20(2):189-99
pubmed: 23466620