Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats.
Alfentanil
/ administration & dosage
Analgesics, Opioid
/ administration & dosage
Anesthesia, Inhalation
/ veterinary
Anesthetics, Inhalation
/ administration & dosage
Animals
Blood Pressure
/ drug effects
Cats
Cross-Over Studies
Drug Interactions
Fentanyl
/ administration & dosage
Heart Rate
/ drug effects
Infusions, Intravenous
/ veterinary
Isoflurane
/ administration & dosage
Sufentanil
/ administration & dosage
MAC
alfentanil
feline
fentanyl
sufentanil
Journal
Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
Titre abrégé: J Vet Pharmacol Ther
Pays: England
ID NLM: 7910920
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
30
03
2020
revised:
12
05
2020
accepted:
27
05
2020
pubmed:
20
6
2020
medline:
19
5
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Different structurally related phenylpiperidine opioids exhibit different isoflurane-sparing effects in cats. Because minimum alveolar concentration (MAC) in cats is affected only by very high plasma concentrations of some phenylpiperidine opioids, we hypothesized these effects are caused by actions on nonopioid receptors. Using a prospective, randomized, crossover design, six cats were anesthetized with isoflurane, intubated, ventilated, and instrumented. Isoflurane MAC was measured in triplicate using a tail-clamp and bracketing technique. A computer-controlled intravenous infusion using prior pharmacokinetic models targeted plasma concentrations of 60 ng/ml fentanyl, 10 ng/ml sufentanil, or 500 ng/ml alfentanil, and isoflurane MAC was measured in duplicate. Next, naltrexone 0.6 mg/kg was administered to cats hourly during the opioid infusion, and isoflurane MAC was measured in duplicate. Blood was collected during MAC determinations to measure opioid concentrations. Responses were analyzed using repeated measures ANOVA with significance at p < .05. Alfentanil and sufentanil decreased isoflurane MAC by 16.4% and 6.4%, respectively, and these effects were completely reversed by naltrexone. Fentanyl had no significant effect on isoflurane MAC. Alfentanil and sufentanil modestly reduce isoflurane MAC via agonist effects on opioid receptors. However, these effects are too small to justify clinical use of phenylpiperidine opioids as single agents to reduce MAC in cats.
Substances chimiques
Analgesics, Opioid
0
Anesthetics, Inhalation
0
Alfentanil
1N74HM2BS7
Sufentanil
AFE2YW0IIZ
Isoflurane
CYS9AKD70P
Fentanyl
UF599785JZ
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
533-537Subventions
Organisme : UC Davis Center for Companion Animal Health
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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