Graft assessment of the ex vivo perfused porcine kidney using hyperpolarized [1-
ex vivo
hyperpolarized MR
kidney
metabolism
perfusion
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
21
12
2019
revised:
07
05
2020
accepted:
21
05
2020
pubmed:
20
6
2020
medline:
15
5
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Normothermic perfusion is an emerging strategy for donor organ preservation and therapy, incited by the high worldwide demand for organs for transplantation. Hyperpolarized MRI and MRS using [1- Kidneys from four 40-kg Danish domestic pigs were perfused ex vivo with whole blood under normothermic conditions, using an MR-compatible perfusion system. Kidneys were investigated using Four kidneys were successfully perfused for 120 minutes and verified using a DCE perfusion experiment. Renal metabolism was examined using hyperpolarized [1- This study demonstrates the ability to monitor ex vivo graft metabolism and function in a large animal model, resembling human renal physiology. The ability of hyperpolarized MRI and MRS to directly compare the metabolic state of an organ in vivo and ex vivo, in combination with the simple MR implementation of normothermic perfusion, renders this methodology a powerful future tool for graft preservation research.
Substances chimiques
Pyruvic Acid
8558G7RUTR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2645-2655Informations de copyright
© 2020 International Society for Magnetic Resonance in Medicine.
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