Fetal cerebral Doppler changes and outcome in late preterm fetal growth restriction: prospective cohort study.
Adult
Birth Weight
Europe
Female
Fetal Development
Fetal Growth Retardation
/ diagnostic imaging
Fetal Weight
Fetus
/ blood supply
Gestational Age
Humans
Infant, Newborn
Infant, Small for Gestational Age
Live Birth
Middle Cerebral Artery
/ diagnostic imaging
Pregnancy
Prospective Studies
Pulsatile Flow
Reference Values
Rheology
Stillbirth
Ultrasonography, Doppler
Ultrasonography, Prenatal
Umbilical Arteries
/ diagnostic imaging
Waist Circumference
Doppler
adverse outcome
middle cerebral artery
neonatal
umbilical artery
umbilicocerebral ratio
Journal
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
ISSN: 1469-0705
Titre abrégé: Ultrasound Obstet Gynecol
Pays: England
ID NLM: 9108340
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
20
12
2019
revised:
14
05
2020
accepted:
29
05
2020
pubmed:
20
6
2020
medline:
15
12
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
To explore the association between fetal umbilical and middle cerebral artery (MCA) Doppler abnormalities and outcome in late preterm pregnancies at risk of fetal growth restriction. This was a prospective cohort study of singleton pregnancies at risk of fetal growth restriction at 32 + 0 to 36 + 6 weeks of gestation, enrolled in 33 European centers between 2017 and 2018, in which umbilical and fetal MCA Doppler velocimetry was performed. Pregnancies were considered at risk of fetal growth restriction if they had estimated fetal weight and/or abdominal circumference (AC) < 10 The study population comprised 856 women. There were two (0.2%) intrauterine deaths. Median gestational age at delivery was 38 (interquartile range (IQR), 37-39) weeks and birth weight was 2478 (IQR, 2140-2790) g. Compared with infants with normal outcome, those with composite adverse outcome (n = 93; 11%) were delivered at an earlier gestational age (36 vs 38 weeks) and had a lower birth weight (1900 vs 2540 g). The first Doppler observation of MCA pulsatility index < 5 In this prospective multicenter study, signs of cerebral blood flow redistribution were found to be associated with adverse outcome in late preterm singleton pregnancies at risk of fetal growth restriction. Whether cerebral redistribution is a marker describing the severity of fetal growth restriction or an independent risk factor for adverse outcome remains unclear, and whether it is useful for clinical management can be answered only in a randomized trial. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-181Subventions
Organisme : Department of Health
ID : NIHR127976
Pays : United Kingdom
Organisme : Else Kröner-Fresenius-Stiftung
Organisme : Imperial College London
Investigateurs
C Brezinka
(C)
D Casagrandi
(D)
A Cerny
(A)
A Dall'Asta
(A)
R Devlieger
(R)
J Duvekot
(J)
T M Eggebo
(TM)
I Fantasia
(I)
F Ferrari
(F)
N Fratelli
(N)
T Ghi
(T)
O Graupner
(O)
P Greimel
(P)
C Hofstaetter
(C)
D Lo Presti
(DL)
M Georg
(M)
F Macsali
(F)
K Marsal
(K)
P Martinelli
(P)
B Mylrea-Foley
(B)
E Mullins
(E)
E Ostermayer
(E)
A Papageorghiou
(A)
R Peasley
(R)
A Ramoni
(A)
L Sarno
(L)
L Seikku
(L)
S Simeone
(S)
B Thilaganathan
(B)
G Tiralongo
(G)
A Valcamonico
(A)
C Van Holsbeke
(C)
A Vietheer
(A)
Informations de copyright
© 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
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