Heme oxygenase promotes B-Raf-dependent melanosphere formation.
Cell Adhesion
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Extracellular Matrix
/ drug effects
Focal Adhesions
/ drug effects
Gene Expression Regulation
/ drug effects
HEK293 Cells
Heme Oxygenase (Decyclizing)
/ antagonists & inhibitors
Humans
Male
Melanocytes
/ drug effects
Mutation
/ genetics
NF-E2-Related Factor 2
/ metabolism
Oncogenes
Proto-Oncogene Mas
Proto-Oncogene Proteins B-raf
/ metabolism
Protoporphyrins
/ pharmacology
Spheroids, Cellular
/ drug effects
Bach1
Heme Oxygenase-1
NFE2L2
antioxidant
extracellular matrix proteins
melanoma
melanosphere
neoplastic stem cells
proto-oncogene proteins B-Raf
reactive oxygen species
Journal
Pigment cell & melanoma research
ISSN: 1755-148X
Titre abrégé: Pigment Cell Melanoma Res
Pays: England
ID NLM: 101318927
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
16
01
2020
revised:
09
05
2020
accepted:
07
06
2020
pubmed:
20
6
2020
medline:
13
8
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Biosynthesis and degradation of heme, an iron-bound protoporphyrin molecule utilized by a wide variety of metabolic processes, are tightly regulated. Two closely related enzymes, heme oxygenase 1 (HMOX1) and heme oxygenase 2 (HMOX2), degrade free heme to produce carbon monoxide, Fe
Identifiants
pubmed: 32558263
doi: 10.1111/pcmr.12905
pmc: PMC7572722
mid: NIHMS1617243
doi:
Substances chimiques
MAS1 protein, human
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
Proto-Oncogene Mas
0
Protoporphyrins
0
cobaltiprotoporphyrin
63AAN3JDZE
Heme Oxygenase (Decyclizing)
EC 1.14.14.18
BRAF protein, human
EC 2.7.11.1
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
850-868Subventions
Organisme : NCCIH NIH HHS
ID : P50 AT006273
Pays : United States
Organisme : NIH HHS
ID : NIH 1 P50 AT006273
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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