The hERG channel activator, RPR260243, enhances protective

Action Potentials Animals Anti-Arrhythmia Agents / pharmacology Arrhythmias, Cardiac / metabolism Disease Models, Animal ERG1 Potassium Channel / agonists Ether-A-Go-Go Potassium Channels / agonists Heart Rate / drug effects Kinetics Myocytes, Cardiac / drug effects Oocytes Piperidines / pharmacology Quinolines / pharmacology Refractory Period, Electrophysiological Signal Transduction Xenopus laevis Zebrafish Zebrafish Proteins / agonists
arrhythmia deactivation hERG protective currents optical mapping post-repolarization refractory zERG zebrafish

Journal

American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228

Informations de publication

Date de publication:
01 08 2020
Historique:
pubmed: 20 6 2020
medline: 8 10 2020
entrez: 20 6 2020
Statut: ppublish

Résumé

Human ether-à-go-go related gene (hERG) K

Identifiants

DOI: 10.1152/ajpheart.00038.2020 PMID: 32559136
pubmed: 32559136
doi: 10.1152/ajpheart.00038.2020
doi:

Substances chimiques

Anti-Arrhythmia Agents 0
ERG1 Potassium Channel 0
Erg protein, zebrafish 0
Ether-A-Go-Go Potassium Channels 0
KCNH2 protein, human 0
Piperidines 0
Quinolines 0
RPR260243 0
Zebrafish Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

H251-H261

Subventions

Organisme : CIHR
ID : 156168
Pays : Canada

Auteurs

Yu Patrick Shi (YP)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

ZhaoKai Pang (Z)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

Ravichandra Venkateshappa (R)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

Marvin Gunawan (M)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

Jacob Kemp (J)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

Elson Truong (E)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

Cherlene Chang (C)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

Eric Lin (E)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.
ORCID: 0000-0002-0905-7105

Sanam Shafaattalab (S)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.
ORCID: 0000-0002-1127-8409

Shoaib Faizi (S)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

Kaveh Rayani (K)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.
ORCID: 0000-0002-8858-8982

Glen F Tibbits (GF)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

Victoria E Claydon (VE)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

Thomas W Claydon (TW)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, British Columbia, Canada.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Eucaryotes › Animaux › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Antiarythmiques › The hERG channel activator, RPR260243,...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques éther-à-go-go › Canal potassique ERG1 › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques éther-à-go-go › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Rythme cardiaque › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Cellules › Cellules germinales › Ovocytes › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Période réfractaire en électrophysiologie › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Xenopus laevis › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › The hERG channel activator, RPR260243,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Protéines de poisson-zèbre › The hERG channel activator, RPR260243,...